Transmission of the major skin microbiota, <i>Malassezia</i>, from mother to neonate

Nagata, Rie; Nagano, Hiroshi; Ogishima, Daiki; Nakamura, Yasushi; Hiruma, Masataro; Sugita, Takashi

doi:10.1111/j.1442-200x.2012.03563.x

Cited by 85 publications

(65 citation statements)

References 21 publications

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“…While cutaneous mycobiome investigations of healthy Asian individuals based in Japan [3, 4, 22, 54–56], Korea [5], and India [57] have been conducted, investigations on Chinese individuals have been limited to prokaryote communities [12, 52, 58]. By selecting only Chinese subjects in our study, our cohort is a representative model of the Chinese population in HK, and while subjects in this study may not represent other Chinese individuals [58], this study is nonetheless fundamental in beginning to understand the skin mycobiome of the Chinese.…”

Section: Discussionmentioning

confidence: 99%

Skin fungal community and its correlation with bacterial community of urban Chinese individuals

Leung

Chan²,

Lee

2016

Microbiome

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BackgroundHigh-throughput sequencing has led to increased insights into the human skin microbiome. Currently, the majority of skin microbiome investigations are limited to characterizing prokaryotic communities, and our understanding of the skin fungal community (mycobiome) is limited, more so for cohorts outside of the western hemisphere. Here, the skin mycobiome across healthy Chinese individuals in Hong Kong are characterized.ResultsBased on a curated fungal reference database designed for skin mycobiome analyses, previously documented common skin colonizers are also abundant and prevalent in this cohort. However, genera associated with local terrains, food, and medicine are also detected. Fungal community composition shows interpersonal (Bray-Curtis ANOSIM = 0.398) and household (Bray-Curtis ANOSIM = 0.134) clustering. Roles of gender and age on diversity analyses are test- and site-specific, and, contrary to bacteria, the effect of household on fungal community composition dissimilarity between samples is insignificant. Site-specific, cross-domain positive and negative correlations at both community and operational taxonomic unit levels may uncover potential relationships between fungi and bacteria on skin.ConclusionsThe studied Chinese population presents similar major fungal skin colonizers that are also common in western populations, but local outdoor environments and lifestyles may also contribute to mycobiomes of specific cohorts. Cohabitation plays an insignificant role in shaping mycobiome differences between individuals in this cohort. Increased understanding of fungal communities of non-western cohorts will contribute to understanding the size of the global skin pan-mycobiome, which will ultimately help understand relationships between environmental exposures, microbial populations, and the health of global humans.Electronic supplementary materialThe online version of this article (doi:10.1186/s40168-016-0192-z) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Skin fungal community and its correlation with bacterial community of urban Chinese individuals

Leung

Chan²,

Lee

2016

Microbiome

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“…The skin mycobiome, for example, is thought to change drastically early in life. Using the genotyping of Malassezia species as an indicator, one study demonstrated that it takes 30 days for the skin microbiota to change from its initial state to an adult type [44]. …”

Section: Composition and Role Of The Mycobiome In Health And Diseasementioning

confidence: 99%

The human mycobiome in health and disease

2013

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The mycobiome, referring primarily to the fungal biota in an environment, is an important component of the human microbiome. Despite its importance, it has remained understudied. New culture-independent approaches to determine microbial diversity, such as next-generation sequencing methods, are greatly broadening our view of fungal importance. An integrative analysis of current studies shows that different body sites harbor specific fungal populations, and that diverse mycobiome patterns are associated with various diseases. By interfacing with other biomes, as well as with the host, the mycobiome probably contributes to the progression of fungus-associated diseases and plays an important role in health and disease.

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“…Interestingly, it has also been shown that the common fungal commensal Malassezia colonizes neonate skin during the birthing process [46]. At day 0 following delivery, Malassezia DNA was successfully detected in 24 of 27 subjects, and by day 30 approximately 10 4 residents were estimated by qPCR.…”

Section: Host Factors and The Skin Microbiotamentioning

confidence: 99%

Interactions between host factors and the skin microbiome

SanMiguel

Grice

2014

Cell. Mol. Life Sci.

130

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The skin is colonized by an assemblage of microorganisms which, for the most part, peacefully coexist with their hosts. In some cases, these communities also provide vital functions to cutaneous health through the modulation of host factors. Recent studies have illuminated the role of anatomical skin site, gender, age, and the immune system in shaping the cutaneous ecosystem. Alterations to microbial communities have also been associated with, and likely contribute to, a number of cutaneous disorders. This review focuses on the host factors that shape and maintain skin microbial communities, and the reciprocal role of microbes in modulating skin immunity. A greater understanding of these interactions is critical to elucidating the forces that shape cutaneous populations and their contributions to skin homeostasis. This knowledge can also inform the tendency of perturbations to predispose and/or bring about certain skin disorders.

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Transmission of the major skin microbiota, Malassezia, from mother to neonate

Abstract: Fungal microbiota colonization of neonates began on day 0, and the fungal microbiota of neonates had changed to the adult type by day 30. To our knowledge, this is the first report of a molecular analysis of the fungal microbiota of neonates.

Cited by 85 publications

References 21 publications

Skin fungal community and its correlation with bacterial community of urban Chinese individuals

Skin fungal community and its correlation with bacterial community of urban Chinese individuals

The human mycobiome in health and disease

Interactions between host factors and the skin microbiome

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