This study presents the potential of using photoplethysmography (PPG) as an alternative to the use of expensive spectroscopy or invasive skin biopsy to analyse skin conditions, particularly of the presence or absence of melanin in both dorsal and palmar skin of human subjects. This study seeks to analyse the sensing capabilities of three photodetectors (phototransistor, light dependent resistor, photodiode) vis-à-vis varying LED colors and quantities using backscatter radiation. Further, it intends to distinguish the best detector and LED color-quantity combination for the sensing of PPG signal in both dorsal and palmar skin of human volunteers. Photoplethysmography (PPG) is considered as a facile and cost effective optical process frequently used for monitoring heart rate. A light source or emitter and a light sensor or detector make up a PPG circuit. A light emitting diode (LED) is the frequently used light source while phototransistor, photodiode or light dependent resistor are the usual light sensors or detector employed. The simulation results revealed that four pieces of yellow LED and phototransistor detector are the best combination for applications involving the melanin in dorsal and palmar skin. The results further showeddirect proportionality relationship between reflected light and age.