Background The Coronavirus has crossed the geographical borders of various countries without any restrictions. This study was performed to identify the epidemiological trends of coronavirus disease (COVID-19) in Iran during February 19 to March 22, 2020.Methods This cross sectional study was carried out in 31 provinces by using the daily number of newly infected cases which was announced by the Iranian health authorities from February 19 to March 22, 2020, we explore the trend of outbreak of coronavirus disease in all provinces of Iran and determine some influential factors such as population size, area, population density, distance from original epicenter, altitude, and human development index (HDI) for each province on its spread by Spearman correlation coefficient. K-means cluster analysis (KMCA) also categorized the provinces into 10 separate groups based on CF and ACF of the infected cases at the end of the study period. (ACF).Results There were 21,638 infected, 7,913 recovered and 2,299 death cases with COVID-19 in Iran during the study period. By March 22, CF shows that, most cases are attributed to Tehran province, while ACF shows that most are attributed to Semnan province. There was a positive significant correlation between CF of the infected cases and province population sizes (r=0.45), HDI (r=0.58); province population density (r=0.47); a negative significant correlation between the CF of the infected cases and distance from original epicenter (r=-0.47). KMCA results based on CF showed very high level of outbreak was in Tehran while KMCA based on ACF showed very high level of outbreak were in Semnan and Qom provinces.Conclusions Special attention is needed for the provinces nearer to the original epicenter which are high risk spots in terms of the severe prevalence of COVID-19. In the absence of definite treatment for this infectious disease, the effective solutions to reduce the transmission of the disease are early isolation of the cases, quarantine for close contacts both in families and community and observing personal hygiene.