The potential signal-to-noise ratio (SNR) gain at ultrahigh field strengths offers the promise of higher image resolution in single-shot diffusion-weighted echo-planar imaging the challenge being reduced T 2 and T 2 * relaxation times and increased B 0 inhomogeneity which lead to geometric distortions and image blurring. These can be addressed using parallel imaging (PI) methods for which a greater range of feasible reduction factors has been predicted at ultrahigh field strengths-the tradeoff being an associated SNR loss. Using comprehensive simulations, the SNR of high-resolution diffusion-weighted echo-planar imaging in combination with spinecho and stimulated-echo acquisition is explored at 7 T and compared to 3 T. To this end, PI performance is simulated for coil arrays with a variable number of circular coil elements. Beyond that, simulations of the point spread function are performed to investigate the actual image resolution. When higher PI reduction factors are applied at 7 T to address increased image distortions, high-resolution imaging benefits SNR-wise only at relatively low PI reduction factors. On the contrary, it features generally higher image resolutions than at 3 T due to smaller point spread functions. The SNR simulations are confirmed by phantom experiments. Finally, high-resolution in vivo images of a healthy volunteer are presented which demonstrate the feasibility of higher PI reduction factors at 7 T in practice. Magn Reson Med 67:679-690, 2012. V C 2011 Wiley Periodicals, Inc.Key words: high-resolution diffusion-weighted imaging; echoplanar imaging; signal-to-noise ratio; parallel imaging; ultrahigh field strengths Diffusion-weighted imaging is a powerful noninvasive magnetic resonance imaging technique that relies on the measurement of the restricted Brownian motion of water molecules to deduce microscopic tissue structure in vivo. Although the biophysical basis is not clearly understood, quantitative measures can be derived that exhibit biomarkers in various pathological states, the most prominent being ischemic stroke (1). Diffusion-weighted imaging is clinically promising since the acquisition is noninvasive, relatively fast and requires neither contrast agents nor ionizing radiation. In addition, dedicated tracking algorithms have been developed that allow for the reconstruction of virtual fiber pathways in the human brain which enable presurgical planning and image-guided surgery (2,3).Great potential arises for diffusion-weighted imaging at ultrahigh field strengths through the theoretically associated signal-to-noise ratio (SNR) gain which offers the promise of higher achievable image resolution. Recently, ultrahigh field scanners with 7 T have been introduced to the scientific community. Yet, diffusion-weighted imaging at 7 T is hampered by increased B 0 inhomogeneity which scales linearly with the main magnetic field strength as well as faster T 2 and T 2 * decay. Image acquisition typically relies on single-shot diffusion-weighted (DW) echo-planar imaging (EPI) due to its spe...