Transmittance Properties of Flurandrenolide Tape for Psoriasis: Helpful Adjunct to Phototherapy

Setaluri, V.; Clark, Adele; Feldman, Steven R.

doi:10.1177/120347540000400404

Cited by 2 publications

(1 citation statement)

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“…Meanwhile, ranolazine therapy is safe and well tolerated in a pilot study involving pulmonary arterial hypertension [34]. Although we can not find the direct evidence for the associations of flurandrenolide and scalp dermatoses, flurandrenolide topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions [35].…”

Section: Resultsmentioning

confidence: 99%

Drug repositioning based on individual bi-random walks on a heterogeneous network

et al. 2019

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BackgroundTraditional drug research and development is high cost, time-consuming and risky. Computationally identifying new indications for existing drugs, referred as drug repositioning, greatly reduces the cost and attracts ever-increasing research interests. Many network-based methods have been proposed for drug repositioning and most of them apply random walk on a heterogeneous network consisted with disease and drug nodes. However, these methods generally adopt the same walk-length for all nodes, and ignore the different contributions of different nodes.ResultsIn this study, we propose a drug repositioning approach based on individual bi-random walks (DR-IBRW) on the heterogeneous network. DR-IBRW firstly quantifies the individual work-length of random walks for each node based on the network topology and knowledge that similar drugs tend to be associated with similar diseases. To account for the inner structural difference of the heterogeneous network, it performs bi-random walks with the quantified walk-lengths, and thus to identify new indications for approved drugs. Empirical study on public datasets shows that DR-IBRW achieves a much better drug repositioning performance than other related competitive methods.ConclusionsUsing individual random walk-lengths for different nodes of heterogeneous network indeed boosts the repositioning performance. DR-IBRW can be easily generalized to prioritize links between nodes of a network.

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Section: Resultsmentioning

confidence: 99%