Transmural Disease of the Alimentary Tract

Mathews, James E.; Peterson, Robert F.; Eberts, John P.; White, Raleigh R.

doi:10.1097/00000658-197106010-00014

Cited by 3 publications

References 4 publications

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Does local intestinal ascorbate deficiency predispose to fistula formation in Crohn's disease

Pettit

Irving

1987

Diseases of the Colon &Amp; Rectum

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Samples of maximally diseased and adjacent macroscopically normal intestine from 52 patients undergoing surgery for Crohn's disease were analyzed for ascorbate content; 26 of the patients had intestinal fistulas and 26 did not. Ascorbate analyses were also performed on samples of normal intestine from ten control patients. Diseased intestine from both groups of patients with Crohn's disease contained significantly more ascorbate than the adjacent macroscopically normal intestine. Their diseased intestine also contained significantly more ascorbate than normal intestine from controls. Whereas diseased intestine from patients without fistulas contained 47 percent more ascorbate than their normal intestine (P less than .001), the diseased intestine from patients with fistulas contained only 23 percent more ascorbate than their normal intestine (P less than .02). Patients with fistulas appear unable to concentrate as much ascorbate in their diseased intestine as patients without fistulas. This difference may be a factor in the pathogenesis of fistula formation in Crohn's disease because of the importance of ascorbate in collagen production.

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Does local intestinal ascorbate deficiency predispose to fistula formation in Crohn's disease

Pettit

Irving

1987

Diseases of the Colon &Amp; Rectum

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Complications

Kyle

1972

Crohn's Disease

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Incidence, Diagnosis, and Treatment of Enteric and Colorectal Fistulae in Patients with Crohnʼs Disease

Michelassi¹,

Stella²,

Balestracci³

et al. 1993

Annals of Surgery

144

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Fistulae are diagnosed preoperatively in 69% of cases and can be suspected in as many as 42% of patients with an abdominal mass. Fistulae are the primary or single indication for surgical treatment and are directly responsible for a stoma only in a few patients. Treatment, based on resection of the diseased bowel and extirpation of the fistula, can be accomplished with minimal morbidity and mortality.

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Transmural Disease of the Alimentary Tract

Cited by 3 publications

References 4 publications

Does local intestinal ascorbate deficiency predispose to fistula formation in Crohn's disease

Does local intestinal ascorbate deficiency predispose to fistula formation in Crohn's disease

Complications

Incidence, Diagnosis, and Treatment of Enteric and Colorectal Fistulae in Patients with Crohnʼs Disease

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