Transmurality of scar influences the effect of a hybrid-intervention with autologous bone marrow cell injection and aortocoronary bypass surgery (MNC/CABG) in patients after myocardial infarction

Müller‐Ehmsen, Jochen; Tossios, Paschalis; Schmidt, Matthias; Scheid, Christof; Ünal, Nermin; Bovenschulte, H.; Hackenbroch, M. H.; Krug, Barbara; Goßmann, Axel; Mehlhorn, Uwe; Schwinger, Robert H. G.; Erdmann, Erland

doi:10.1016/j.ijcard.2010.11.010

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…A potential explanation for the latter finding may be that early reperfusion after AMI leads to lower infarct transmurality but not to a lower infarct size or to less microvascular obstruction, as shown previously. 17 In agreement with the results of a smaller trial, 18 we suggest that in patients with complete transmural scar, BM-MNC treatment may be less beneficial. Further analyses of the 12-month CMR data, currently under way, will reveal whether remodeling is favorably affected by BM-MNC therapy in the long run.…”

Section: Discussionsupporting

confidence: 83%

Intracoronary Injection of Bone Marrow–Derived Mononuclear Cells Early or Late After Acute Myocardial Infarction

Sürder¹,

Manka²,

Cicero³

et al. 2013

Circulation

183

117

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Background-Intracoronary administration of autologous bone marrow-derived mononuclear cells (BM-MNC) mayimprove remodeling of the left ventricle (LV) after acute myocardial infarction. The optimal time point of administration of BM-MNC is still uncertain and has rarely been addressed prospectively in randomized clinical trials. Methods and Results-In a multicenter study, we randomized 200 patients with large, successfully reperfused ST-segment elevation myocardial infarction in a 1:1:1 pattern into an open-labeled control and 2 BM-MNC treatment groups. In the BM-MNC groups, cells were administered either early (ie, 5 to 7 days) or late (ie, 3 to 4 weeks) after acute myocardial infarction. Cardiac magnetic resonance imaging was performed at baseline and after 4 months. The primary end point was the change from baseline to 4 months in global LV ejection fraction between the 2 treatment groups and the control group. The absolute change in LV ejection fraction from baseline to 4 months was −0.4±8.8% (mean±SD; P=0.74 versus baseline) in the control group, 1.8±8.4% (P=0.12 versus baseline) in the early group, and 0.8±7.6% (P=0.

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Section: Discussionsupporting

confidence: 83%

Intracoronary Injection of Bone Marrow–Derived Mononuclear Cells Early or Late After Acute Myocardial Infarction

Sürder¹,

Manka²,

Cicero³

et al. 2013

Circulation

183

117

View full text Add to dashboard Cite

show abstract

“…The differences might be explained by a variation in responses due to differing severity of cryoinjuries. In accord with this, another group (Muller-Ehmsen et al, 2012) explored the role of infarct transmurality on the therapeutic effect of bone marrow mononuclear cells after myocardial infarction and showed scar size reduction and improved myocardial function only in patients with non-transmural myocardial infarcts but not transmural lesions.…”

Section: Discussionmentioning

confidence: 92%

Differential regenerative capacity of neonatal mouse hearts after cryoinjury

Darehzereshki

Rubin

Gamba

et al. 2015

Developmental Biology

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Neonatal mouse hearts fully regenerate after ventricular resection similar to adult zebrafish. We established cryoinjury models to determine if different types and varying degrees of severity in cardiac injuries trigger different responses in neonatal mouse hearts. In contrast to ventricular resection, neonatal mouse hearts fail to regenerate and show severe impairment of cardiac function post transmural cryoinjury. However, neonatal hearts fully recover after non-transmural cryoinjury. Interestingly, cardiomyocyte proliferation does not significantly increase in neonatal mouse hearts after cryoinjuries. Epicardial activation and new coronary vessel formation occur after cryoinjury. The profibrotic marker PAI-1 is highly expressed after transmural but not non-transmural cryoinjuries, which may contribute to the differential scarring. Our results suggest that regenerative medicine strategies for heart injuries should vary depending on the nature of the injury.

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Absolute Resting 13N-Ammonia PET Myocardial Blood Flow for Predicting Myocardial Viability and Recovery of Ventricular Function after Coronary Artery Bypass Grafting

Wang

et al. 2022

Journal of Nuclear Cardiology

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Transmurality of scar influences the effect of a hybrid-intervention with autologous bone marrow cell injection and aortocoronary bypass surgery (MNC/CABG) in patients after myocardial infarction

Cited by 6 publications

References 35 publications

Intracoronary Injection of Bone Marrow–Derived Mononuclear Cells Early or Late After Acute Myocardial Infarction

Intracoronary Injection of Bone Marrow–Derived Mononuclear Cells Early or Late After Acute Myocardial Infarction

Differential regenerative capacity of neonatal mouse hearts after cryoinjury

Absolute Resting 13N-Ammonia PET Myocardial Blood Flow for Predicting Myocardial Viability and Recovery of Ventricular Function after Coronary Artery Bypass Grafting

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