Transmyocardial laser revascularization preserves regional myocardial perfusion: an MRI first pass perfusion study

Abstract

TMLR preserves regional myocardial perfusion and improves function as shown with MRPI.

Discrimination of Myocardial Acute and Chronic (Scar) Infarctions on Delayed Contrast Enhanced Magnetic Resonance Imaging With Intravascular Magnetic Resonance Contrast Media

“…Eight weeks after infarction is widely considered chronic infarction in humans (21), pigs (22), sheep (23,24), and dogs (6). Animals were then killed, and the hearts were excised and sliced (10 mm).…”

“…A limiting factor of the current study is that infarcts of only 2 time durations (3 days and 8 weeks) were studied. Eight weeks after infarction seems reasonable, because it has been widely considered chronic infarction in humans and animals (21)(22)(23)(24). The use of 2 MR contrast media for discriminating acute from chronic infarctions is rather time consuming, and this might limit the clinical application.…”

Assessment of Ischemic Heart Disease Using Magnetic Resonance First-Pass Perfusion Imaging

“…More recently, we developed a model-independent approach that does not make any specific assumptions about the shape of the impulse response and uses regularization for robust deconvolution [9]. Fermi-constrained and model-independent deconvolutions have been validated in animal experiments by comparison to measurements with labeled microspheres [9,25]. With constrained deconvolution, a perfusion reserve can also be calculated from the ratio of the maximum amplitudes of the impulse response for rest and hyperemia.…”

“…Besides the ability to assess collateral development after implantation of an ameroid constrictor (see Figure 2 and Jerosch-Herold & Wilke [10]), MR perfusion imaging has already been used to follow up improvement of myocardial perfusion in animals after therapeutic angiogenesis [29] and other methods of revascularization such as transmyocardial laser revascularization [25].…”

“…Recently, magnetic resonance (MR) first-pass perfusion imaging has been shown to allow absolute quantification of myocardial perfusion and perfusion reserve [9,25]. A close correlation between CFR and MPR in patients has been demonstrated [38].…”