Transnasal High-Flow Oxygen Therapy versus Noninvasive Positive Pressure Ventilation in the Treatment of COPD with Type II Respiratory Failure: A Meta-Analysis

Abstract

Objective. To compare the safety and efficacy of transnasal high-flow oxygen therapy (HFNT) and noninvasive positive pressure ventilation (NIV) in the treatment of chronic obstructive pulmonary disease (COPD) with type II respiratory failure. Methods. PubMed, the Cochrane Library, Embase, CBM, CNKI, and other databases were searched for randomized controlled trials (RCTS) on the efficacy of HFNT and NIV in the treatment of COPD. Meta-analysis was conducted using RevMan 5.3 software after two researchers screened literatures, extracted data, and evaluated the methodological quality of the included studies according to inclusion and exclusion criteria. Results. A total of 948 patients were included in 12 RCTS. Comprehensive analysis results showed that the HFNC group had higher levels of 12 h-PAO2, 48 h-PACO2 and, 48 h-pH than the NIV group, and the differences were statistically significant ( P < 0.05 ). There were no significant differences in 24 h-PAO2 and 72 h-PAO2, 12 h-PACO2, 24 h-PACO2 and 72 h-PACO2, 24 h-pH, 48 h-pH, and 72 h-pH between the two groups after treatment ( P > 0.05 ). Conclusions. Compared with NIV, HFNC does not increase the treatment failure rate in COPD patients with type II respiratory failure, and HFNC has better comfort and tolerance, which is a new potential respiratory support treatment for COPD patients with type II respiratory failure.

Analysis of therapeutic effects on type II respiratory failure and impact on blood gas changes: high-flow nasal oxygen therapy vs. non-invasive positive pressure ventilation

“…A higher score indicates a more severe condition and a higher predicted mortality. (3) Complications: Incidence of complications during the treatment period was recorded. Complications included gastric distension, nasal bleeding, aspiration, and facial pressure injuries.…”

“…Diagnostic criteria for type II respiratory failure include an arterial oxygen partial pressure (PaO 2 ) below 60 mmHg and an arterial carbon dioxide partial pressure (PaCO 2 ) exceeding 50 mmHg. This disease is characterized by a rapid onset, swift progression, and a notably high mortality rate, significantly impacting patient survival [3,4]. Consequently, prompt and efficacious interventions are imperative in the management of type II acute respiratory failure, with the goal of alleviating clinical symptoms and reducing mortality.…”

Effects of high-flow nasal cannula oxygen therapy for patients with acute exacerbation of chronic obstructive pulmonary disease in combination with type II respiratory failure

“…It is characterized by airflow limitation with persistent and progressive dyspnea and is often accompanied by chronic coughing and chest tightness. [1][2] Acute exacerbations of COPD (AECOPD) are more common in middle-aged and older patients, often occur in combination with type II respiratory failure, and are characterized by weak coughing, concomitant infection, and poor lung function, which have negative effects on patient health, and increase the risks of hospitalization, readmission and disease progression. As AECOPD worsens, CO 2 retention and hypercapnic respiratory failure may occur.…”

Retracted: Transnasal High‐Flow Oxygen Therapy versus Noninvasive Positive Pressure Ventilation in the Treatment of COPD with Type II Respiratory Failure: A Meta‐Analysis

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”