Transoral laser resections of oral cavity and oropharyngeal tumors

Introduction. Surgical approach for oral cancer treatment is one of the key factors that determines oncologic effectiveness, risk of postoperative complications, need for reconstructive methods etc. Currently, there exists lack of strict criteria for using one or another approaches based on the sound scientific evidence for a primary tumor of given depth of invasion.Aim. The aim of the study is a retrospective comparative analysis of oncologic efficiency of transoral and combined approaches for surgical treatment of tongue and floor of the mouth moderately advanced carcinoma.Materials and methods. 75 patients aged between 30 and 80 years with tongue and floor of the mouth squamous cell carcinoma with depth of invasion from 10 to 20 mm were included into the study. In 29 cases the tumor was resected transorally (Group 1), in 45 – via combined approach (Group 2). Group 2 patients had more advanced tumors both locally and regionally. 13 patients of Group 1 and 27 patients of Group 2 underwent adjuvant radiotherapy. The following parameters were used for comparative analysis: the rate of local and regional recurrence, locoregional control, the rate of distant metastasis and Kaplan–Meyer overall survival.Results. Mean follow up was 33.77 ± 27.72 months (range 14–115 months). The rate of local and regional recurrence was higher in Group 2 (20 % vs 10.3 % and 22.2 % vs 17.2 % respectively). Locoregional control was better in Group 1 (72.4 % vs 62.2 %). The difference for neither of the above-mentioned parameters did not reach statistical significance. Median survival was statistically significantly better in Group 1: 66 ± 17.42 months vs 23 ± 3.85 months (p = 0.030). Poorer treatment results in Group 2 can be explained by a higher proportion of patients with more advanced tumors in this group.Conclusion. The results of the present study do not allow to conclude that combined approach has oncologic advantage over less aggressive transoral approach for tumors with depth of invasion from 10 to 20 mm. It is questionable to recommend the combined approach as a universal one for lesions with such a stage of local invasiveness.

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Comparison of transoral and combined approach for surgical treatment of moderately advanced tongue and floor of the mouth cancer

Карпенко

Сибгатуллин

Boyko

et al. 2023

Opuholi golovy i šei

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Low-Intensity Laser Radiation in Correction of Blood Hemodynamic and Rheological Parameters After Surgery for Head and Neck Cancer

et al. 2020

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Purpose: to study the effect of low-level laser therapy (LLLT) in correction of blood hemodynamic and rheological parameters after surgery for head and neck cancer.Material and Methods. The study included 134 head and neck cancer patients with a median age of 54.24 ± 12.7 years (range: 23–78 years). There were 39 (29.1 %) men and 95 (70.9 %) women. To assess the effectiveness of LLLT, all patients were divided into 3 groups. Group I included 45 patients, who received conventional therapy without the use of LLLT. Group II consisted of 45 patients, who received conventional therapy in combination with LLLT. Group III included 44 patients, who received LLLT alone. Azor 2K-02 was used as a source of LLLT in the red to near infrared spectral range. Characteristics of blood flow in the vessels of the neck and the rheological properties of blood, as well as the parameters of spontaneous platelet aggregation and the content of soluble fibrinmonomer complexes in the blood plasma of patients were studied.Results. The data obtained indicated that the use of LLLT promoted normalization of blood rheological properties in patients, who underwent surgery. Normalization of blood rheological properties occurred faster and lasted for a longer period. In patients, who received conventional therapy in combination with LLLT, the hemodynamic and rheological parameters of blood were improved 2–14 days after therapy, whereas in patients receiving conventional therapy alone, this improvement was seen 30 or more days after therapy.Conclusion. LLLT in combination with conventional therapy was shown to have a positive effect on hemodynamic and rheological parameters after surgery for head and neck cancer.

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Clinical case of aggressive course of hyperplasia of the lingual tonsil

Shlyaga,

Miazheinikava,

Cheliabiyeva

et al. 2024

jour

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The article describes a clinical case of atypical aggressive progression of mycosis-associated hyperplasia of the lingual tonsil with proliferative changes in the pharyngeal and palatine tonsils. The features of etiology, pathogenesis, diagnostic challenges, and an effective treatment method for this pathology are presented. Based on clinical experience, it is important to note that the prevalence of lingual tonsil diseases is significantly higher than their detectability. This is attributed to its anatomical-topographical and morphological characteristics of location and structure, as well as the relative difficulty of examination (due to a high pharyngeal reflex), the need for the specialist physician to master hypopharyngoscopy techniques, and the lack of a clear algorithm for clinical examination of such patients.

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Transoral laser resections of oral cavity and oropharyngeal tumors

Cited by 3 publications

References 10 publications

Comparison of transoral and combined approach for surgical treatment of moderately advanced tongue and floor of the mouth cancer

Comparison of transoral and combined approach for surgical treatment of moderately advanced tongue and floor of the mouth cancer

Low-Intensity Laser Radiation in Correction of Blood Hemodynamic and Rheological Parameters After Surgery for Head and Neck Cancer

Clinical case of aggressive course of hyperplasia of the lingual tonsil

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