Transosseous Temperature Monitoring of the Anterior Epidural Space during Thermal Ablation in the Thoracic Spine

Development and preclinical evaluation of multifunctional hydrogel for precise thermal protection during thermal ablation

“…Further in vivo evaluations of the HA-Dc hydrogel during the TA procedure were carried out with a rabbit BFM ablation model. We focused on thermal protection, the most important requirement for the HA-Dc hydrogel, and we chose neuroprotection as the evaluation index since the nerves are more sensitive to temperature and have a lower temperature threshold at which damage occurs (42 °C) [ 55 , 56 ]. An RF electrode was inserted into the BFM directly (control group) or after the BFM and SN were separated by hydrodissection material (HA-Dc hydrogel, 5% Glu, or F127).…”

“…This new hydrogel should first have good retention so that it can remain at the injection site and maintain sufficient displacement of the vulnerable structures throughout the ablation procedure. Second, and most importantly, the hydrogel should provide adequate thermal protection, even for more thermosensitive structures such as nerves, which have a lower temperature threshold for induced thermal injury (42 °C) [ 55 , 56 ] than other major organs (over 60 °C) [ 58 , 59 ]. Third, the hydrogel should also have good biocompatibility and controllable degradation in vivo within a finite period.…”

Temperature Monitoring in Hyperthermia Treatments of Bone Tumors: State-of-the-Art and Future Challenges

“…This study aimed at evaluating the efficacy of bipolar radiofrequency ablation with a target temperature of 70 °C. A study similar to [ 51 ] was carried out by the same research group in 2021 [ 158 ]. In this article, the authors suggested a combined technique of temperature monitoring and hydrodissection within the anterior epidural space in seven patients affected by thoracic metastases.…”