Transovarial development of scrub typhus rickettsiae in a colony of vector mites

Rapmund, Garrison; Upham, Robert W.; Kundin, W. D.; Manikumaran, C.; Chan, Teik Chye

doi:10.1016/0035-9203(69)90155-2

Cited by 45 publications

(28 citation statements)

References 7 publications

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“…Several investigators succeeded in rearing rickettsiainfected mites in the laboratory and demonstrated transovarial transmission of the rickettsiae from the female parents to the progeny (2,3). In the rickettsiainfected families, most of the progeny contained rickettsiae, but some uninfected progeny were also found (2,3,5). On the other hand, the distribution of rickettsiae in the body of these infected mites has been observed in Leptotrombidium fletcheri by immunofluorescent microscopy (6), and in L. arenicola by electron microscopy (14).…”

mentioning

confidence: 99%

Electron Microscopic Study of the Distribution and the Vertical Transmission of Rickettsia Tsutsugamushi in Leptotrombidium Pallidum

Urakami

Takahashi

Murata³

et al. 1994

JJMSB

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confidence: 99%

Electron Microscopic Study of the Distribution and the Vertical Transmission of Rickettsia Tsutsugamushi in Leptotrombidium Pallidum

Urakami

Takahashi

Murata³

et al. 1994

JJMSB

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“…Mites serve as reservoirs and the bacterium is maintained in successive mite generations by transovarial transmission. [1][2][3][4][5] The chigger infects a rodent or human host when feeding on tissue fluid. [6][7][8] With no vaccine, scrub typhus prevention is a major challenge and infections may be fatal if untreated.…”

Section: Introductionmentioning

confidence: 99%

Characterization Based on the 56-Kda Type-Specific Antigen Gene of Orientia tsutsugamushi Genotypes Isolated from Leptotrombidium Mites and the Rodent Host Post-Infection

Takhampunya¹,

Tippayachai²,

Promsathaporn³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Characterization of the 56-kDa type-specific antigen (TSA) genes of Orientia tsutsugamushi (OT) from three naturally infected, laboratory-reared mite colonies comprising three species (Leptotrombidium deliense [Ld], Leptotrombidium imphalum [Li], and Leptotrombidium chiangraiensis [Lc]) has revealed the presence of single and coexisting OT genotypes found in individual chiggers. The Karp genotype was found in all of the chiggers examined, whereas Gilliam and UT302 genotypes were only observed in combination with the Karp genotype. From analysis of these OT genotypes after transmission from chiggers to mice it was determined that with the Lc and Li mites, the OT genotype composition in the rodent spleens post-infection had not changed and therefore resembled that observed in the feeding chiggers. However, only the Karp genotype was found in rodents after feeding by Ld chiggers carrying Karp and Gilliam genotypes. The current findings reveal a complex association among the host, pathogen, and vector.

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“…Then, what are the mechanisms favorable for the maintenance or the increase of the number of Rt-carrying mites ? It has been reported by Rapmund's group that Rt is maintained by transovarial transmission in Rtcarrying colonies of L. fletcheri and L. arenicola that are known to be Rt-vector mites in Malaysia, and that most of the Rt-carrying mites were female (1,(11)(12)(13)(14)19). These and other authors have also reported that when non-Rt-carrying larvae were fed on infected laboratory mice, only a few of them acquired Rt through feeding, and no vertical transmission to the next generation through the egg was observed (10,18), though the number of mites examined was small.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Studies on the Background of the Endemic Occurrence of Tsutsugamushi Disease in Toyama Prefecture

Ishikura

Watanabe

Morita

et al. 1985

Microbiology and Immunology

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In order to clarify the epidemiological background of the endemic occurrence of tsutsugamushi disease in Toyama Prefecture, Japan, since 1978, comparative surveys have been carried out between endemic and nonendemic areas. Rickettsia tsutsugamushi (Rt) was isolated at a rate of about 36% (158/439) from field rodents in the endemic area while it was not isolated from any of 280 in nonendemic areas. In all of six stations in the endemic area, a significantly high proportion of rodents were found to be Rt carriers. However, no Rt was isolated from rodents captured from July to September. The organism was isolated from rodents captured in the other months, especially in a high proportion in November when infestation of rodents with Leptotrombidium pallidum was at its peak. When the rodents were examined by indirect immunofluorescence staining, the rate of anti-Rt antibodypositive animals was about 55% (157/287) and about 17% (62/368) in endemic and nonendemic areas, respectively. Larvae of mites collected from the rodents were found to belong to four genera and 11 species. Among them L. pallidum was the only mite that had been known to be a vector of Rt. L. pallidum was found most frequently and in abundance from rodents in the endemic area, whereas it was present in very small numbers in rodents in nonendemic areas. The infestation of rodents with L. pallidum showed a seasonal variation, i.e. two peaks per year, in spring and autumn, and the number of mites detected was markedly greater in November than in spring. Rt was isolated from L. pallidum on rodents captured in the endemic area.

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Transovarial development of scrub typhus rickettsiae in a colony of vector mites

Cited by 45 publications

References 7 publications

Electron Microscopic Study of the Distribution and the Vertical Transmission of Rickettsia Tsutsugamushi in Leptotrombidium Pallidum

Electron Microscopic Study of the Distribution and the Vertical Transmission of Rickettsia Tsutsugamushi in Leptotrombidium Pallidum

Characterization Based on the 56-Kda Type-Specific Antigen Gene of Orientia tsutsugamushi Genotypes Isolated from Leptotrombidium Mites and the Rodent Host Post-Infection

Epidemiological Studies on the Background of the Endemic Occurrence of Tsutsugamushi Disease in Toyama Prefecture

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