Transparency of industry payments needed in clinical practice guidelines

Vassar, Matt; Bibens, Michael; Wayant, Cole

doi:10.1136/bmjebm-2018-111020

Cited by 9 publications

(2 citation statements)

References 10 publications

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“…As we found that 22% of organizations did not have publicly available COI policies and that 11% of CPGs did not include author COI disclosures, organizations need to commit to greater transparency, a policy that both physicians and non-physicians are increasingly adopting regarding research [32]. The establishment of the Open Payments Program has helped improve transparency [33], and by making use of it, multiple studies have demonstrated that COI disclosures among CPG authors are often incomplete [16,17,34].…”

Section: Plos Onementioning

confidence: 97%

Analysis of conflict of interest policies among organizations producing clinical practice guidelines

2021

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Background Conflicts of interest (COI) jeopardize the validity of Clinical Practice Guidelines (CPGs). When the Institute of Medicine promulgated COI policies in 2011, few organizations met these requirements, but it is unknown if organizations have improved their policies since that time. We sought to evaluate current adherence to IOM standards of COI policies. Methods and findings We conducted a retrospective document review of COI policies and CPGs from organizations that published five or more CPGs between January 1, 2018 and December 31, 2019. Organizations were identified via CPG databases. COI policies were obtained from an internet search. We collected data on i) the number of organizations that have COI policies specific to CPG development, ii) the number of policies meeting each IOM standard and iii) the number of IOM standards met by each policy. COI disclosures from five CPGs of each organization were assessed for adherence to IOM standards. Among the 46 organizations that published 5 or more CPGs, 36 (78%) had a COI policy. Standard 2.2b (requiring divestment of financial COI) was met least frequently, by 2 of 36 (6%) organizations. Standard 2.1 (requiring disclosure of COI) was met most frequently, by 33 of 36 (92%) organizations. A total of 31 of 36 (86%) organizations met 4 or fewer of the 7 IOM standards. Among the 16 organizations limiting COI to a minority of the CPG panel (standard 2.4c) and the 15 organizations prohibiting COI among chairs or co-chairs (standard 2.4d), 12 (75%) and 10 (67%) organizations violated the respective standard in at least one CPG. The main limitations of our study are the exclusion of organizations producing fewer CPGs and ability to assess only publicly available policies. Conclusion Among organizations producing CPGs, COI policies frequently do not meet IOM standards, and organizations often violate their own policies. These shortcomings may undermine the public trust in and thus the utility of CPGs. CPG-producing organizations should improve their COI policies and their strategies to manage COI to increase the trustworthiness of CPGs.

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Section: Plos Onementioning

confidence: 97%

Analysis of conflict of interest policies among organizations producing clinical practice guidelines

2021

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“…For example, the EFPIA requires all members to have disclosure policies, but, in many cases, compliance with these policies is not regulated. 135 Internationally, we recommend that governing bodies create a regulated, mandatory, and verifiable database to shed light on COIs around the world. It is important to note that disclosure does not not eliminate the risk of bias.…”

Section: Recommendations For Clinical Researchmentioning

confidence: 99%

Ten years later: a review of the US 2009 institute of medicine report on conflicts of interest and solutions for further reform

Torgerson

Wayant

Cosgrove

et al. 2020

BMJ EBM

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Conflicts of interest (COIs) in healthcare are increasingly discussed in the literature, yet these relationships continue to influence healthcare. Research has consistently shown that financial COIs shape prescribing practices, medical education and guideline recommendations. In 2009, the Institute of Medicine (IOM, now the National Academy of Medicine) published Conflicts of Interest in Medical Research, Practice, and Education—one of the most comprehensive reviews of empirical research on COIs in medicine. Ten years after publication of theIOM’s report, we review the current state of COIs within medicine. We also provide specific recommendations for enhancing scientific integrity in medical research, practice, education and editorial practices.

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Conflicts of interest in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews: associations with recommendations

Nejstgaard

Bero²,

Hróbjartsson

et al. 2020

Cochrane Database of Systematic Reviews

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Transparency of industry payments needed in clinical practice guidelines

Cited by 9 publications

References 10 publications

Analysis of conflict of interest policies among organizations producing clinical practice guidelines

Analysis of conflict of interest policies among organizations producing clinical practice guidelines

Ten years later: a review of the US 2009 institute of medicine report on conflicts of interest and solutions for further reform

Conflicts of interest in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews: associations with recommendations

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