Recent advances in material innovation and structural design provide routes to flexible hybrid electronics that can combine the high‐performance electrical properties of conventional wafer‐based electronics with the ability to be stretched, bent, and twisted to arbitrary shapes, revolutionizing the transformation of traditional healthcare to digital healthcare. Here, material innovation and structural design for the preparation of flexible hybrid electronics are reviewed, a brief chronology of these advances is given, and biomedical applications in bioelectrical monitoring and stimulation, optical monitoring and treatment, acoustic imitation and monitoring, bionic touch, and body‐fluid testing are described. In conclusion, some remarks on the challenges for future research of flexible hybrid electronics are presented.