Transparent ultrasound transducers for multiscale photoacoustic imaging

Chen, Haoyang; Osman, Mohamed; Mirg, Shubham; Agrawal, Sumit; Cai, Jiacheng; Dangi, Ajay; Kothapalli, Sri Rajasekhar

doi:10.1117/12.2579056

Cited by 10 publications

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“…MRR sensors usually have a wider bandwidth than other types of US sensors [43,44,54,55]. The piezoelectricbased sensors maintain high sensitivity over a wide bandwidth [26,28,31,61]. The CMUT sensors generally have high sensitivity over a narrower bandwidth [33,34].…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

“…Therefore, transparent PMN-PT ceramics and single crystals will become the materials with better application prospects for transparent US transducers due to their higher temperature stability and higher piezoelectric performance. In 2021, Chen et al reported a PMN-PT single crystal-based transparent US senor with a 14 MHz center frequency [61].…”

Section: Transparent Piezoelectric-based Us Sensorsmentioning

confidence: 99%

“…Estimated sensitivity of transparent US sensors and their bandwidth. FP1[40], FP2[42], MRR[22], Piezo-PVDF[26], Piezo-LN1[31], Piezo-LN2[60], Piezo-PMN-PT[61], CMUT1[34], CMUT2[33].…”

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confidence: 99%

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A Review of Transparent Sensors for Photoacoustic Imaging Applications

et al. 2021

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Photoacoustic imaging is a new type of noninvasive, nonradiation imaging modality that combines the deep penetration of ultrasonic imaging and high specificity of optical imaging. Photoacoustic imaging systems employing conventional ultrasonic sensors impose certain constraints such as obstructions in the optical path, bulky sensor size, complex system configurations, difficult optical and acoustic alignment, and degradation of signal-to-noise ratio. To overcome these drawbacks, an ultrasonic sensor in the optically transparent form has been introduced, as it enables direct delivery of excitation light through the sensors. In recent years, various types of optically transparent ultrasonic sensors have been developed for photoacoustic imaging applications, including optics-based ultrasonic sensors, piezoelectric-based ultrasonic sensors, and microelectromechanical system-based capacitive micromachined ultrasonic transducers. In this paper, the authors review representative transparent sensors for photoacoustic imaging applications. In addition, the potential challenges and future directions of the development of transparent sensors are discussed.

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Section: Discussion and Perspectivesmentioning

confidence: 99%

Section: Transparent Piezoelectric-based Us Sensorsmentioning

confidence: 99%

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A Review of Transparent Sensors for Photoacoustic Imaging Applications

et al. 2021

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“…These crystals exhibit near perfect transparency, an ultrahigh piezoelectric coefficient, an excellent electromechanical coupling factor, and a large electro-optical coefficient. Dangi et al [138] applied this transparent PMN-PT based US transducer in PA imaging. This high sensitivity transparent US transducer could provide more flexibility of probe design, further facilitating the translation of this endoscopic PA imaging technology to clinical use.…”

Section: Discussionmentioning

confidence: 99%

Advances in Endoscopic Photoacoustic Imaging

Zhou

et al. 2021

Photonics

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Photoacoustic (PA) imaging is able to provide extremely high molecular contrast while maintaining the superior imaging depth of ultrasound (US) imaging. Conventional microscopic PA imaging has limited access to deeper tissue due to strong light scattering and attenuation. Endoscopic PA technology enables direct delivery of excitation light into the interior of a hollow organ or cavity of the body for functional and molecular PA imaging of target tissue. Various endoscopic PA probes have been developed for different applications, including the intravascular imaging of lipids in atherosclerotic plaque and endoscopic imaging of colon cancer. In this paper, the authors review representative probe configurations and corresponding preclinical applications. In addition, the potential challenges and future directions of endoscopic PA imaging are discussed.

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“…For example, the above mentioned glass as the first backing may be replaced by a transparent epoxy block coated with low temperature ITO deposition as a conductive connection for the ground to reduce the significant mass-loading effect from the glass slide. Further a two matching layer approach [52] or novel matching layers that use translucent particles (glass beads) also have the potential to help improve the transmit and receive bandwidths of the TUT arrays. For reducing the grating lobes, a geometry of fully diced through piezoelectric material would help reduce the cross-talk, which will likely reduce the grating lobes presented.…”

Section: Quad-mode Imaging Validationmentioning

confidence: 99%

A Transparent Ultrasound Array for Real-time Optical, Ultrasound and Photoacoustic Imaging

Chen

Agrawal

Osman

et al. 2021

Preprint

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Objective and Impact StatementSimultaneous imaging of ultrasound and optical contrasts can help map structural, functional and molecular biomarkers inside living subjects with high spatial resolution. There is a need to develop a platform to facilitate this multimodal imaging capability to improve diagnostic sensitivity and specificity.IntroductionCurrently, combining ultrasound, photoacoustic and optical imaging modalities is challenging because con-ventional ultrasound transducer arrays are optically opaque. As a result, complex geometries are used to co-align both optical and ultrasound waves in the same field of view.MethodsOne elegant solution is to make the ultrasound transducer transparent to light. Here, we demonstrate a novel transparent ultrasound transducer (TUT) liner array fabricated using a transparent lithium niobate piezoelectric material for real-time multimodal imaging.ResultsThe TUT array consisted of 64 elements and centered at ∼ 6 MHz frequency. We demonstrate a quad-mode ultrasound, Doppler ultrasound, photoacoustic and fluorescence imaging in real-time using the TUT array directly coupled to the tissue mimicking phantoms.ConclusionThe TUT array successfully showed a multimodal imaging capability, and has potential applications in diagnosing cancer, neuro and vascular diseases, including image-guided endoscopy and wearable imaging.

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Transparent ultrasound transducers for multiscale photoacoustic imaging

Cited by 10 publications

References 0 publications

A Review of Transparent Sensors for Photoacoustic Imaging Applications

A Review of Transparent Sensors for Photoacoustic Imaging Applications

Advances in Endoscopic Photoacoustic Imaging

A Transparent Ultrasound Array for Real-time Optical, Ultrasound and Photoacoustic Imaging

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