Transperineal Injection of Hyaluronic Acid in Anterior Perirectal Fat to Decrease Rectal Toxicity From Radiation Delivered With Intensity-Modulated Brachytherapy or EBRT for Prostate Cancer Patients: In Regard to Prada et al. (Int J Radiat Oncol Biol Phys 2007;69:95–102.)

Vordermark, Dirk; Gückenberger, Matthias; Baier, Kurt; Markert, Klaus

doi:10.1016/j.ijrobp.2007.12.053

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…The costs incurred with these risk factors have not been included. As discussed by Vordermark et al [29], the side effects of the injection must be followed prospectively.…”

Section: Discussionmentioning

confidence: 99%

Spacers in radiotherapy treatment of prostate cancer: Is reduction of toxicity cost-effective?

Vanneste

Pijls‐Johannesma

Voorde

et al. 2015

Radiotherapy and Oncology

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“…The costs incurred with these risk factors have not been included. As discussed by Vordermark et al [29], the side effects of the injection must be followed prospectively.…”

Section: Discussionmentioning

confidence: 99%

Spacers in radiotherapy treatment of prostate cancer: Is reduction of toxicity cost-effective?

Vanneste

Pijls‐Johannesma

Voorde

et al. 2015

Radiotherapy and Oncology

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“…Four patients reported slight discomfort directly after the injection. As discussed by Vordermark et al [23], side effects of the injection will be followed prospectively. The hydrogel injection was not feasible in one patient.…”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of a hydrogel spacer for rectal separation in dose-escalated intensity-modulated radiotherapy for clinically localized prostate cancer

et al. 2013

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BackgroundAs dose-escalation in prostate cancer radiotherapy improves cure rates, a major concern is rectal toxicity. We prospectively assessed an innovative approach of hydrogel injection between prostate and rectum to reduce the radiation dose to the rectum and thus side effects in dose-escalated prostate radiotherapy.MethodsAcute toxicity and planning parameters were prospectively evaluated in patients with T1-2 N0 M0 prostate cancer receiving dose-escalated radiotherapy after injection of a hydrogel spacer. Before and after hydrogel injection, we performed MRI scans for anatomical assessment of rectal separation. Radiotherapy was planned and administered to 78 Gy in 39 fractions.ResultsFrom eleven patients scheduled for spacer injection the procedure could be performed in ten. In one patient hydrodissection of the Denonvillier space was not possible. Radiation treatment planning showed low rectal doses despite dose-escalation to the target. In accordance with this, acute rectal toxicity was mild without grade 2 events and there was complete resolution within four to twelve weeks.ConclusionsThis prospective study suggests that hydrogel injection is feasible and may prevent rectal toxicity in dose-escalated radiotherapy of prostate cancer. Further evaluation is necessary including the definition of patients who might benefit from this approach. Trial registration: German Clinical Trials Register DRKS00003273.

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“…Tumor disappearance and no pulmonary or skin damage were observed to last for 3 years (lower panels). brachytherapy (26). We hereby recommend an optimal use of natural HA sufficient for the desired term.…”

Section: Discussionmentioning

confidence: 97%

Critical Organ Preservation in Reirradiation Brachytherapy by Injectable Spacer

Kishi¹,

Sonomura²,

Shirai³

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Transperineal Injection of Hyaluronic Acid in Anterior Perirectal Fat to Decrease Rectal Toxicity From Radiation Delivered With Intensity-Modulated Brachytherapy or EBRT for Prostate Cancer Patients: In Regard to Prada et al. (Int J Radiat Oncol Biol Phys 2007;69:95–102.)

Cited by 7 publications

References 4 publications

Spacers in radiotherapy treatment of prostate cancer: Is reduction of toxicity cost-effective?

Spacers in radiotherapy treatment of prostate cancer: Is reduction of toxicity cost-effective?

Prospective evaluation of a hydrogel spacer for rectal separation in dose-escalated intensity-modulated radiotherapy for clinically localized prostate cancer

Critical Organ Preservation in Reirradiation Brachytherapy by Injectable Spacer

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