Objectives-The accurate, rapid diagnosis of stress urinary incontinence (SUI) in women can profoundly improve their sexual and psychosocial life. In this study, the diagnostic power of SUI was assessed by transperineal ultrasound.Methods-In this hospital-based case-control study, married women who were referred to the gynecologic and ultrasound wards with negative urinalysis and culture results were enrolled by random sampling. Patients with positive cough signs based on the urodynamic testing data were considered cases, whereas control women showed no cough symptoms and were recruited from the same ward.Results-There was a significant difference (P < .001) in bladder neck descent (mean AE SD, 10.89 AE 5.51 versus 7.08 AE 2.60 mm, respectively; P = .0001) and the retrovesical (β) angle with the Valsalva maneuver (144.22 AE 19.63 versus 111.81 AE 24.47 ; P < .001) between the case and control groups. Also, the β angle without the Valsalva maneuver was higher in the case group (112.35 AE 23.10 ) than the control group (120.17 AE 25.16 ; P = .001). There was no case of a urinary leak, urethral diverticulitis, a bladder stone or mass, and cystourethrocele in the patients of each group. The results of multivariate logistic regression with a backward method showed that bladder neck descent (odds ratio [OR], 1.24; 95% confidence interval [CI], 1.09-1.40), the β angles with and without the Valsalva maneuver (OR, 1.1; 95% CI, 1.06-1.13; and OR, 1.04; 95% CI, 1.01-1.06) were the predictors of SUI. A β angle higher than 127 with the Valsalva maneuver, with an area under the curve of 0.89 (95% CI, 0.75-0.96), could very well predict the SUI response. This finding shows that it can be very well used to distinguish between normal and non-normal responses, with 89% sensitivity and 79% specificity.Conclusions-The β angle with the Valsalva maneuver could very well predict the SUI response. Key Words-diagnosis; female urogenital diseases; retrovesical angle; stress urinary incontinence; transperineal ultrasound S tress urinary incontinence (SUI) is one of the crucial pelvic floor disorders, affecting many women around the world. 1 This disease occurs with an incidence rate ranging from 10% to 30% in different ethnicities/races. 2 Stress urinary incontinence is defined as unintended urine leakage by coughing, sneezing, lifting, or laughing, which can rigorously impair the patient's quality of life 3 and negatively affect her social and sexual life. Women with this problem will avoid social gatherings and lose