Transplacental exposure to environmental carcinogens: Association with childhood cancer risks and the role of modulating factors

Fučić, Aleksandra; Guszak, Vedrana; Mantovani, Alberto

doi:10.1016/j.reprotox.2017.06.044

Cited by 26 publications

(17 citation statements)

References 128 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Topoisomerase II inhibition through maternal dietary sources in close to 100 mothers was significantly associated with increased AML risk in infants with a mixed lineage leukemia (MLL) gene translocation [29]. Although the associations with alcohol, caffeine, and smoking are most frequently observed in childhood ALL, they are also seen in other types of childhood leukemia, lymphoma, Wilms' tumor, and brain cancer with transplacental exposures to these factors [30].…”

Section: Associations Between Nutrition and The Development Of Childhood Leukemiamentioning

confidence: 99%

Diet as a Potential Moderator for Genome Stability and Immune Response in Pediatric Leukemia

Wang

Maxwell

Akella

2021

Cancers

View full text Add to dashboard Cite

Pediatric leukemias are the most prevalent cancers affecting children in developed societies, with childhood acute lymphoblastic leukemia (ALL) being the most common subtype. As diet is a likely modulator of many diseases, this review focuses on the potential for diet to influence the incidence and progression of childhood ALL. In particular, the potential effect of diets on genome stability and immunity during the prenatal and postnatal stages of early childhood development are discussed. Maternal diet plays an integral role in shaping the bodily composition of the newborn, and thus may influence fetal genome stability and immune system development. Indeed, higher birth weights of newborns are associated with increased risk of ALL, which suggests in-utero biology may shape the evolution of preleukemic clones. Postnatally, the ingestion of maternal breastmilk both nourishes the infant, and provides essential components that strengthen and educate the developing immune system. Consistently, breast-feeding associates with decreased risk of ALL development. For children already suffering from ALL, certain dietary regimens have been proposed. These regimens, which have been validated in both animals and humans, alter the internal hormonal environment. Thus, hormonal regulation by diet may shape childhood metabolism and immunity in a manner that is detrimental to the evolution or expansion of preleukemic and leukemic ALL clones.

show abstract

Section: Associations Between Nutrition and The Development Of Childhood Leukemiamentioning

confidence: 99%

Diet as a Potential Moderator for Genome Stability and Immune Response in Pediatric Leukemia

Wang

Maxwell

Akella

2021

Cancers

View full text Add to dashboard Cite

show abstract

“…The worldwide incidence of childhood cancer is estimated at 140 per million person-years and is increasing ( 1 – 3 ). The etiology of childhood cancer is largely unknown but thought to be explained by both pre- and postnatal factors ( 4 – 6 ). The increasing incidence of childhood cancer could point to environmental risk factors that have changed over time ( 2 – 4 ).…”

Section: Abbreviationsmentioning

confidence: 99%

Maternal Medication Use and Childhood Cancer in Offspring—Systematic Review and Considerations for Researchers

Hjorth

Hemmingsen

Bénevent

et al. 2021

American Journal of Epidemiology

View full text Add to dashboard Cite

Cancer is an important cause of childhood mortality, yet the etiology is largely unknown. A combination of pre- and postnatal factors is thought to be implicated, including maternal medication use. We aimed to provide 1) a systematic review of peer-reviewed publications on associations between maternal medication use and childhood cancer with a focus on study design and methodology, and 2) suggestions for how to increase transparency, limit potential biases, and improve comparability in studies on maternal medication use and childhood cancer. We conducted a systematic search in the PubMed, Embase, Scopus, Cochrane, and Web of Science databases until June 8th 2020. Altogether, 112 studies were identified. The reviewed studies were heterogeneous in study design, exposure, and outcome classification. In 21 studies (19%), the outcome was any childhood cancer. Of the 91 papers that reported on specific types of cancer, 62% did not report the cancer classification system. The most frequently investigated medication groups were sex hormones (46 studies, excluding fertility medications), and anti-infectives (37 studies). Suggestions for strengthening future pharmacoepidemiological studies on maternal medication use and childhood cancer relate to choice of cancer classification system, exposure windows, and methods for identification of -, and control for, potential confounders.

show abstract

“…CYP3A4 is probably the most important CYP enzyme for metabolism of chemicals, and for this reason, the induction and variability of CYP3A4 are important modifying factors in a large number of chemical‐induced toxicities, especially regarding pharmaceuticals . For example, anticancer therapy‐related adverse effects have been associated with CYP3A4 variability due to induction and genetic polymorphisms in breast, prostate, gynaecological and colorectal cancers , and consequently, the interest of using nuclear receptor activation and target gene induction as biomarkers for revealing potential risks and for the translation into successful treatments of diseases has grown during the recent years .…”

Section: The Central Role Of Xenobiotic Receptors and Cyp Induction Imentioning

confidence: 99%

Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

Hakkola

Bernasconi

Coecke

et al. 2018

Basic Clin Pharma Tox

View full text Add to dashboard Cite

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon receptor (AHR) and peroxisome proliferator-activated receptor α (PPARα) are ligand-activated transcription factors that regulate expression of many xenobiotic-metabolizing enzymes including several cytochrome P450 (CYP) enzymes. Many xenobiotics induce CYP enzymes through these intracellular receptors and consequently affect toxicokinetics and possible metabolic activation of the receptor ligands and other xenobiotics utilizing similar metabolic pathways. However, it is now apparent that the xenobiotic receptors regulate also many endogenous functions and signalling pathways, and xenobiotic exposure thus may dysregulate an array of fundamental cell functions. This MiniReview surveys and discusses the multifaceted roles of xenobiotic receptors, for which CYP induction may serve as the first alert and possibly a biomarker for exposure to xenobiotics. With the current emergence of the adverse outcome pathway (AOP) concept, these receptors are being and will be assigned as molecular initiating events or key events in numerous discrete toxicity pathways.

show abstract

Transplacental exposure to environmental carcinogens: Association with childhood cancer risks and the role of modulating factors

Cited by 26 publications

References 128 publications

Diet as a Potential Moderator for Genome Stability and Immune Response in Pediatric Leukemia

Diet as a Potential Moderator for Genome Stability and Immune Response in Pediatric Leukemia

Maternal Medication Use and Childhood Cancer in Offspring—Systematic Review and Considerations for Researchers

Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

Contact Info

Product

Resources

About