Transplacental Infection with Non-Cytopathic Bovine Viral Diarrhoea Virus Types 1b and 2: Viral Spread and Molecular Neuropathology

Bielefeldt‐Ohmann, Helle; Tolnay, A.-E.; Reisenhauer, C.E.; Hansen, Thomas; Смирнова, Н. П.; Campen, Hana Van

doi:10.1016/j.jcpa.2007.10.006

Cited by 46 publications

(56 citation statements)

References 65 publications

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“…Recently, Bielefeldt-Ohmann and colleagues described the decreased number of GFAP-immunoreactive astorocytes in bovine fetus persistently infected with NCP BVDV, which might be an in vivo collaboration of our in vitro observations [1]. Further studies will be required to elucidate the molecular interaction between viral infection and astroglial differentiation.…”

Section: Green) E) Gfap-expressing Cells With Relatively Broad Cytopsupporting

confidence: 53%

Non-Cytopathic Bovine Viral Diarrhea Virus Infection Inhibits Differentiation of Bovine Neural Stem/progenitor Cells into Astrocytes in Vitro

Matsuda

Kobayashi

Kameyama

et al. 2010

The Journal of Veterinary Medical Science

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ABSTRACT. Bovine viral diarrhea virus (BVDV) causes fetal brain malformations in ruminants when the fetuses are infected transplacentally in mid-pregnancy. In both cytopathic and non-cytopatic virus infections, viral lytic infection in actively replicating cells and interruption of vascular integrity have been suggested as the pathogenesis, but functional disturbance of infected neural developing cells has been unclear. In this study, we examined the effect of infection with non-cytopathic BVDV2 on the differentiation of neural stem/precursor cells isolated from the bovine fetus. In the process of differentiation to three types of neural cells, neurons, astrocytes and oligodendrocytes, virus infection significantly and selectively inhibited the differentiation of neural stem/precursor cells into the astrocytic lineage. This inhibition is possibly important for the pathogenesis of congenital brain malformations associated with non-cytopathic BVDV infection.KEY WORDS: astrocyte, bovine viral diarrhea virus, central nervous system, differentiation, neural stem cell.

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Section: Green) E) Gfap-expressing Cells With Relatively Broad Cytopsupporting

confidence: 53%

Non-Cytopathic Bovine Viral Diarrhea Virus Infection Inhibits Differentiation of Bovine Neural Stem/progenitor Cells into Astrocytes in Vitro

Matsuda

Kobayashi

Kameyama

et al. 2010

The Journal of Veterinary Medical Science

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“…Samples from the lungs, hilar lymph nodes, tonsils, and spleens were immunolabeled for influenza A virus nuclear protein (NP) with a mouse monoclonal antibody (Fitzgerald Industries Intern) (14) or rabbit polyclonal antibody (anti-HK/97; CDC Influenza Branch), for myeloid cells with Mac387 (DAKO), for dendritic cells with anti-CD83 (13), and for activated caspase-3 (Cell Signaling Technology). The protocols used have been described (13,15,52). All microscopy was performed on an Olympus BX41 light microscope (Olympus).…”

Section: Virusesmentioning

confidence: 99%

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

Baskin

Bielefeldt‐Ohmann

Tumpey

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

334

336

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The mechanisms responsible for the virulence of the highly pathogenic avian influenza (HPAI) and of the 1918 pandemic influenza virus in humans remain poorly understood. To identify crucial components of the early host response during these infections by using both conventional and functional genomics tools, we studied 34 cynomolgus macaques (Macaca fascicularis) to compare a 2004 human H5N1 Vietnam isolate with 2 reassortant viruses possessing the 1918 hemagglutinin (HA) and neuraminidase (NA) surface proteins, known conveyors of virulence. One of the reassortants also contained the 1918 nonstructural (NS1) protein, an inhibitor of the host interferon response. Among these viruses, HPAI H5N1 was the most virulent. Within 24 h, the H5N1 virus produced severe bronchiolar and alveolar lesions. Notably, the H5N1 virus targeted type II pneumocytes throughout the 7-day infection, and induced the most dramatic and sustained expression of type I interferons and inflammatory and innate immune genes, as measured by genomic and protein assays. The H5N1 infection also resulted in prolonged margination of circulating T lymphocytes and notable apoptosis of activated dendritic cells in the lungs and draining lymph nodes early during infection. While both 1918 reassortant viruses also were highly pathogenic, the H5N1 virus was exceptional for the extent of tissue damage, cytokinemia, and interference with immune regulatory mechanisms, which may help explain the extreme virulence of HPAI viruses in humans.1918 pandemic ͉ functional genomics ͉ H5N1

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“…103,104 Lesions of leukomalacia and infiltration of the meninges and neuropil by macrophages and neutrophils were seen. 11,104 The fetal brain is infected via infiltrating microglial precursor cells (ameboid glial cells), and vasculopathy occurs around the time of viral invasion. This is followed by microvascular loss (presumably by necrosis), which either leads to or is concurrent with microcavity formation or cysts that persist and may enlarge over subsequent weeks.…”

Section: Special Pathologymentioning

confidence: 99%

Bovine Viral Diarrhea Virus Infections

Brodersen

2014

Vet Pathol

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Bovine viral diarrhea virus (BVDV) continues to be of economic significance to the livestock industry in terms of acute disease and fetal loss. Many of the lesions relating to BVDV infection have been well described previously. The virus is perpetuated in herds through the presence of calves that are persistently infected. Relationships between various species and biotypes of BVDV and host defenses are increasingly understood. Understanding of the host defense mechanisms of innate immunity and adaptive immunity continues to improve, and the effects of the virus on these immune mechanisms are being used to explain how persistent infection develops. The noncytopathic biotype of BVDV plays the major role in its effects on the host defenses by inhibiting various aspects of the innate immune system and creation of immunotolerance in the fetus during early gestation. Recent advances have allowed for development of affordable test strategies to identify and remove persistently infected animals. With these improved tests and removal strategies, the livestock industry can begin more widespread effective control programs.

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Transplacental Infection with Non-Cytopathic Bovine Viral Diarrhoea Virus Types 1b and 2: Viral Spread and Molecular Neuropathology

Cited by 46 publications

References 65 publications

Non-Cytopathic Bovine Viral Diarrhea Virus Infection Inhibits Differentiation of Bovine Neural Stem/progenitor Cells into Astrocytes in Vitro

Non-Cytopathic Bovine Viral Diarrhea Virus Infection Inhibits Differentiation of Bovine Neural Stem/progenitor Cells into Astrocytes in Vitro

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

Bovine Viral Diarrhea Virus Infections

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