Transplacental passage of aluminium from pregnant mice to fetus organs after maternal transcutaneous exposure

Abstract

<jats:p> Aluminium is present in tap water, antiperspirants and cosmetics up to 20%. Teratogenicity of aluminium was clearly identified after per os or intravenous administra tion. Malformations and other alterations by aluminium intoxication were evaluated in fetus. In the present study, we investigated the possible transplacental passage of aluminium and its accumulation in the tissue after cutaneous uptake. Female Swiss mice received alumi nium chloride by cutaneous way (0.4 μg/day) during 20 days of gestation. The samples were assayed for alumi nium quantification by graphite furnace atomic absorp tion with Zeeman correction. This treatment led to an increase of aluminium in maternal and fetus samples (serum, amniotic fluid and organs) as compared to controls. </jats:p>

The consequences of aluminium intake on reproductive function in male rats:a three-generation study

“…In our research this phenomenon was present in the F 0 and F 1 generations, but in the F 2 generation was absent, even at 200 ppb AS, denoting, in our opinion, a lack of hypophysis response, and confirming others authors' results who proved that aluminium after absorption passes easily through the rat placenta and via milk in the suckling period, and so can be found in the next generation's tissues and organs (41,42).…”

Underarm cosmetics and breast cancer

“…The skin is no barrier to aluminium absorption (Exley, 1998). Experiments with shaved adult mice, naked mouse pups and excised skin patches taken from adult mice have all shown that topically applied aluminium salts can be absorbed through mouse skin (Anane et al, 1995(Anane et al, , 1997. Furthermore, dermal absorption of aluminium could be detected in human subjects from a single application of aluminium chlorhydrate using the isotope 26 Al as the tracer (Flarend et al, 2001).…”

Aluminium, antiperspirants and breast cancer

“…Whilst it had been assumed that unbroken skin would be an effective barrier to transdermal uptake of aluminium, dermal absorption of topically applied antiperspirant aluminium salts has now been demonstrated through intact mouse skin [25,26] and human skin [27][28][29][30]. Dermal absorption of aluminium was detected in human subjects from a single application of aluminium chlorhydrate using the isotope 26 Al as the tracer [27].…”