Transplacental passage of IgG antibody to group B streptococcus serotype Ia

Boyer, Kenneth M.; Papierniak, Cynthia K.; Gadzala, Cecile A.; Parvin, Jeffrey D.; Gotoff, Samuel P.

doi:10.1016/s0022-3476(84)80564-8

Cited by 47 publications

(22 citation statements)

References 9 publications

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“…At the normal term of delivery cord serum levels ofIgG and IgG subclasses are often found to be approximately 10% greater than the maternal levels (2-5, IS). A similar correlation to gestational age has been observed for levels of antibodies to group B streptococci (6,7). Their presence in cord serum was shown to reduce the susceptibility to neontal group B streptococcal infections (16).…”

Section: Methodssupporting

confidence: 71%

IgG Subclasses and Antibodies to Group B Streptococci, Pneumococci, and Tetanus Toxoid in Preterm Neonates after Intravenous Infusion of Immunoglobulin to the Mothers

Morell¹,

Sidiropoulos

Herrmann

et al. 1986

Pediatr Res

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ABSTRACf. High doses of intravenous immunoglobulin were given to seven pregnant women between the 27th and 36th wk of gestation who were at risk for preterm delivery. Determinations of IgG subclasses and of antibodies against group B streptococcal serotypes, pneumococcal polysaccharides, and tetanus toxoid were done in maternal serum before and after intravenous IgG infusion and after delivery in cord serum. Substantial transplacental passage of the infused material could be observed in five cases where delivery occurred at the 34th wk or later. After the 36th wk of gestation, IgG subclass and antibody concentrations in cord serum were increased up to the levels in the maternal serum. (Pediatr Res 20:933-936, 1986) Abbreviation IGIV, intravenous immunoglobulin Preterm neonates are known to be highly susceptible to systemic bacterial infections (1). This increased risk is due in part to the immaturity of the immune system and to an incomplete transplacental transfer of protective IgG antibodies from the mother (2-7). Sidiropoulos et al. (8) have shown that the administration of IGIV in combination with antibiotics was effective in the treatment of neonatal sepsis, particularly in premature babies. As a consequence of this previous work, the question was asked whether perinatal or prenatal infection could be prevented by giving IGIV to pregnant women who were at risk for preterm delivery. As a first step, we studied the possibility of a transplacental passage of IGIV administered in the last trimenon of pregnancy. This report provides evidence that all four IgG subclasses and various specific antibodies present in the IGIV preparation are transferred from the mothers to the babies. PATIENTSThe study included seven women between the 27th and the 36th wk of pregnancy who were at risk for preterm delivery with preterm labor, rupture of the membranes, or signs of chorioam- nionitis. The gestational age was assessed by serial ultrasonography and examination of the newborns. Informed consent was obtained from all women. Immunoglobulin applications consisted of intravenous infusions of 24 g IgG (Sandoglobulin) at each of5 consecutive days (6% solution in 0.9% saline, 10 drops/ min). In addition, the patients received the antibiotics amoxicillin (4 g/day) and clindamycin (1.8 g/day). Monitoring of pulse and blood pressure, cardiotocography, and clinical observation did not show any side effects attributable to IGIV in mothers and infants. Serum samples were obtained immediately before the first and after the last infusion. In three women in whom delivery was delayed for 8-25 days after the last infusion, additional samples were taken at the time of birth. Cord blood samples were collected at delivery. The serum was kept at -20 0 C until assayed. METHODSIgG subclasses. IgG subclass specific reagents were prepared by immunizing sheep with isolated myeloma proteins and quantitative determinations were done with a solid phase radioimmunoassay as described (9, 10). Binding inhibition curves were established using the WHO r...

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Section: Methodssupporting

confidence: 71%

IgG Subclasses and Antibodies to Group B Streptococci, Pneumococci, and Tetanus Toxoid in Preterm Neonates after Intravenous Infusion of Immunoglobulin to the Mothers

Morell¹,

Sidiropoulos

Herrmann

et al. 1986

Pediatr Res

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“…Recently, immunospecific murine monoclonal IgM antibodies have been viewed with interest as potential immunotherapeutic agents for infants born too prematurely to receive IgG in a theoretically "protective" level (16). The efficacy of murine monoclonal class-specific antibodies for protection in invasive 111-GBS experimental infection is well documented (2,(17)(18).…”

Section: Discussionmentioning

confidence: 99%

Functional Activity of Class-Specific Antibodies to Type III, Group B Streptococcus

et al. 1988

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“…Others have demonstrated an increase in cord blood IgG concentrations to values often considerably greater than those for paired maternal serum samples with increasing length of gestation (2, 1 I, 12, 33), suggesting active transplacental IgG transport. It has been shown also that the concentrations of IgG antibody to specific antigens frequently are greater in cord blood samples than in paired maternal sera later in gestation, although the ratio of cord to maternal antibody concentrations may differ for different antigens (7,13,14).…”

Section: Gestational a G E (Weeks)mentioning

confidence: 99%

“…However, there are relatively few studies of specific antibody transfer in prematurity (2,7,8,14,15), and little is known of the functional capacity of maternally derived antibody in the neonate. Sato et al (14) showed that cord sera from term infants had higher concentrations of neutralizing antibodies to measles, mumps, and rubella than did paired maternal sera.…”

mentioning

confidence: 99%

Maternofetal Transfer of IgG Anti-Escherichia coli Antibodies with Enhanced Avidity and Opsonic Activity in Very Premature Neonates

et al. 1990

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ABSTRACT. Total IgG concentrations, IgG antibody concentrations to pooled Escherichia coli antigens, and IgG anti-E. coli antibody avidity were measured in cord and maternal serum samples collected from 52 mother-infant pairs after premature delivery (mean gestational age 28 wk, range 23-33 wk). The mean IgG anti-E. coli antibody concentration in cord serum (1.86 relative units/mL) was markedly lower than in maternal serum . These findings suggest that there is selective transplacental transport of high avidity antibody with enhanced opsonic activity for these antigens early in the 3rd trimester of pregnancy. (Pediatr Res 27: 365-371, 1990)

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Transplacental passage of IgG antibody to group B streptococcus serotype Ia

Cited by 47 publications

References 9 publications

IgG Subclasses and Antibodies to Group B Streptococci, Pneumococci, and Tetanus Toxoid in Preterm Neonates after Intravenous Infusion of Immunoglobulin to the Mothers

IgG Subclasses and Antibodies to Group B Streptococci, Pneumococci, and Tetanus Toxoid in Preterm Neonates after Intravenous Infusion of Immunoglobulin to the Mothers

Functional Activity of Class-Specific Antibodies to Type III, Group B Streptococcus

Maternofetal Transfer of IgG Anti-Escherichia coli Antibodies with Enhanced Avidity and Opsonic Activity in Very Premature Neonates

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