Transplacental Transmission of<i>Plasmodium falciparum</i>in a Highly Malaria Endemic Area of Burkina Faso

Ouédraogo, Alphonse; Tiono, Alfred B.; Diarra, Amidou; Bougouma, Edith C.; Nébié, Issa; Konaté, Amadou; Sirima, Sodiomon B.

doi:10.1155/2012/109705

Cited by 35 publications

(42 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This shows that the prevalence of infection at delivery has been relatively stable over the years despite the implementation of the IPT p policy in Cameroon. The prevalence of placental malaria parasite infection was lower than that of peripheral malaria parasite infection, which is consistent with some previous observations [17], [24]. It is however contrary to the trends reported by Achidi et al [12], Anchang-Kimbi et al [10] and Leke et al [11] who found prevalence of placental malaria parasite infection higher than that of peripheral malaria parasite infection, as commonly admitted [25].…”

Section: Discussionsupporting

confidence: 90%

“…The prevalence of neonatal malaria parasite infection (6.0%) was lower than the prevalence reported in the South West [12], [30] and Centre Regions of Cameroon [31], but higher than that found by Anchang-Kimbi [32] in Cameroon and Ouédraogo et al [24] in Burkina Faso. A similar value was found in Tanzania [33] and North Central Nigeria [17].…”

Section: Discussioncontrasting

confidence: 61%

See 1 more Smart Citation

Malaria Risk Factors in Women on Intermittent Preventive Treatment at Delivery and Their Effects on Pregnancy Outcome in Sanaga-Maritime, Cameroon

et al. 2013

View full text Add to dashboard Cite

Malaria is known to have a negative impact on pregnant women and their foetuses. The efficacy of Sulfadoxine-Pyrimethamine (SP) used for intermittent preventive treatment (IPT) is being threatened by increasing levels of resistance. This study assessed malaria risk factors in women on intermittent preventive treatment with SP (IPTp-SP) at delivery and their effects on pregnancy outcome in Sanaga-Maritime Division, Cameroon. Socio-economic and obstetrical data of mothers and neonate birth weights were documented. Peripheral blood from 201 mothers and newborns as well as placental and cord blood were used to prepare thick and thin blood films. Maternal haemoglobin concentration was measured. The overall malaria parasite prevalence was 22.9% and 6.0% in mothers and newborns respectively. Monthly income lower than 28000 FCFA and young age were significantly associated with higher prevalence of placental malaria infection (p = 0.0048 and p = 0.019 respectively). Maternal infection significantly increased the risk of infection in newborns (OR = 48.4; p<0.0001). Haemoglobin concentration and birth weight were lower in infected mothers, although not significant. HIV infection was recorded in 6.0% of mothers and increased by 5-folds the risk of malaria parasite infection (OR = 5.38, p = 0.007). Attendance at antenatal clinic and level of education significantly influenced the utilisation of IPTp-SP (p<0.0001 and p = 0.018 respectively). Use of SP and mosquito net resulted in improved pregnancy outcome especially in primiparous, though the difference was not significant. Malaria infection in pregnancy is common and increases the risk of neonatal malaria infection. Preventive strategies are poorly implemented and their utilization has overall reasonable effect on malaria infection and pregnancy outcome.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 61%

Malaria Risk Factors in Women on Intermittent Preventive Treatment at Delivery and Their Effects on Pregnancy Outcome in Sanaga-Maritime, Cameroon

et al. 2013

View full text Add to dashboard Cite

show abstract

“…The prevalence found in this study is similar to the low prevalence of 1.4 % reported in Burkina Faso [9] or 2.2 % reported in Ghana [8], but lower than the numbers reported from studies in Nigeria [6, 17–20]. However comparisons between studies are difficult to make due to the different methodologies being used (type of sample or type of diagnostic test), the different study populations being observed (symptomatic versus asymptomatic newborns) or the different contextual levels of malaria endemicity.…”

Section: Discussionsupporting

confidence: 89%

“…In Accra, Ghana newborns presented with ≤50 parasites/µL [8] and in Burkina Faso, the mean parasite density among newborns was 316 parasites/µL [9]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence and diagnostics of congenital malaria in rural Burundi, a cross-sectional study

Stassijns

Boogaard

Pannus

et al. 2016

Malar J

View full text Add to dashboard Cite

BackgroundCongenital malaria, defined as the presence of asexual forms of malaria parasites in the peripheral blood during the first 7 days of life, remains a neglected area of research. Knowledge gaps exist about prevalence and management of malaria in this age group. The objective of this study was to evaluate the prevalence of congenital malaria and the validity of a rapid diagnostic test (RDT) for its diagnosis in rural Burundi.MethodsA cross-sectional study was conducted in a meso-endemic malaria context in Burundi among 290 mothers, and their newborns (n = 303), who delivered at the maternity departments of Kirundo and Mukenke Hospitals during March and April 2014. Peripheral blood samples were collected from all mothers/newborns pairs in order to examine the presence of malaria parasites with two RDT (SD-Bioline HRP2 and Carestart pan-pLDH) and a blood slide. In addition, quantitative real-time polymerase chain reaction (PCR) was performed from the newborn peripheral sample. Frequencies and proportions were calculated for categorical variables. Sensitivity and specificity were calculated with a 95 % confidence interval (CI).ResultsNone of the newborns were found positive by PCR (0/303; 95 % CI 0.0–1.3). The prevalence in newborns born from microscopy-positive mothers was 0 % (0/44; 95 % CI 0.0–8.0). Two newborns were positive with SD-Bioline HRP2 (0.7 %, 95 % CI 0.2–2.4) but none with Carestart pan-pLDH or microscopy. Sensitivity of the diagnostic tests could not be evaluated as no congenital malaria was detected. Specificity of SD-Bioline HRP2, Carestart pan-pLDH and microscopy to detect congenital malaria was 99.3 % (95 % CI 97.6–99.8), 100.0 % (95 % CI 98.3–100.0) and 100.0 % (95 % CI 98.8–100.0), respectively.ConclusionIn Burundi or the Central African region, no recent prevalence studies for congenital malaria have been carried out. This study found that the prevalence of congenital malaria in two hospitals in Kirundo province is zero. RDT showed to have an excellent specificity and, therefore, can be used to rule out congenital malaria: the risk of overtreatment is low. However, as no cases of congenital malaria were detected, the study was not able to draw conclusions about the sensitivity of the RDT, nor about risk factors for congenital malaria. Further studies evaluating the sensitivity of RDT for diagnosis of congenital malaria are needed.

show abstract

“…Congenital malaria due to P. falciparum is reportedly rare in hyperendemic areas, where pregnant woman can pass on antibodies against the parasite to their newborn babies. Thus, even though maternal asymptomatic malaria is common, congenital malaria is not [8][9][10][11]. However, recent reports suggest that congenital P. falciparum malaria is not as rare as previously believed [12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Congenital Malaria in China

Tao

Fang

et al. 2014

PLoS Negl Trop Dis

View full text Add to dashboard Cite

BackgroundCongenital malaria, in which infants are directly infected with malaria parasites from their mother prior to or during birth, is a potentially life-threatening condition that occurs at relatively low rates in malaria-endemic regions. It is recognized as a serious problem in Plasmodium falciparum–endemic sub-Saharan Africa, where recent data suggests that it is more common than previously believed. In such regions where malaria transmission is high, neonates may be protected from disease caused by congenital malaria through the transfer of maternal antibodies against the parasite. However, in low P. vivax–endemic regions, immunity to vivax malaria is low; thus, there is the likelihood that congenital vivax malaria poses a more significant threat to newborn health. Malaria had previously been a major parasitic disease in China, and congenital malaria case reports in Chinese offer valuable information for understanding the risks posed by congenital malaria to neonatal health. As most of the literature documenting congenital malaria cases in China are written in Chinese and therefore are not easily accessible to the global malaria research community, we have undertaken an extensive review of the Chinese literature on this subject.Methods/Principal FindingsHere, we reviewed congenital malaria cases from three major searchable Chinese journal databases, concentrating on data from 1915 through 2011. Following extensive screening, a total of 104 cases of congenital malaria were identified. These cases were distributed mainly in the eastern, central, and southern regions of China, as well as in the low-lying region of southwest China. The dominant species was P. vivax (92.50%), reflecting the malaria parasite species distribution in China. The leading clinical presentation was fever, and other clinical presentations were anaemia, jaundice, paleness, diarrhoea, vomiting, and general weakness. With the exception of two cases, all patients were cured with antimalarial drugs such as chloroquine, quinine, artemether, and artesunate.ConclusionsThe symptoms of congenital malaria vary significantly between cases, so clear and early diagnosis is difficult. We suggest that active surveillance might be necessary for neonates born to mothers with a history of malaria.

show abstract

Transplacental Transmission ofPlasmodium falciparumin a Highly Malaria Endemic Area of Burkina Faso

Cited by 35 publications

References 25 publications

Malaria Risk Factors in Women on Intermittent Preventive Treatment at Delivery and Their Effects on Pregnancy Outcome in Sanaga-Maritime, Cameroon

Malaria Risk Factors in Women on Intermittent Preventive Treatment at Delivery and Their Effects on Pregnancy Outcome in Sanaga-Maritime, Cameroon

Prevalence and diagnostics of congenital malaria in rural Burundi, a cross-sectional study

Congenital Malaria in China

Contact Info

Product

Resources

About