Transplacental Transmission of Pemphigus

Wasserstrum, Nathan

doi:10.1001/jama.1983.03330350056029

Cited by 60 publications

(35 citation statements)

References 11 publications

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“…In this study, PV and PF occurred in subjects younger than 19 years. A pathomechanism involving transplacental antibody transfer or vertical transmission of pathogenic antibodies has been used to explain neonatal PV and PF . PV and PF are diagnosed most frequently in subjects older than 50 years.…”

Section: Discussionmentioning

confidence: 99%

Incidence and death rate of pemphigus vulgaris and pemphigus foliaceus in Korea: A nationwide, population‐based study (2006–2015)

Lee

et al. 2018

The Journal of Dermatology

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The epidemiology of pemphigus varies among racial populations worldwide. Trends in the incidence of pemphigus have not been investigated based on the Korean National Health Insurance database. This study investigated the incidence and death rate of pemphigus with age using nationwide population data in South Korea. A nationwide population‐based cohort study was performed using the Korean National Health Insurance Claims Database from 2006 to 2015. The incidence of pemphigus vulgaris (PV) per 1 000 000 person‐years was 2.059 (1.885 for males and 2.234 for females), and for pemphigus foliaceus (PF) 1.138 (1.205 males and 1.07 for females). The incidence of PV and PF increased with age. The incidence was not different between the habitat and household income. These incidence of PV and PF was significantly higher in subjects with comorbid metabolic conditions, such as diabetes mellitus, hypertension and dyslipidemia. The death rate per 1000 person‐years in PV and PF patients increased with age after adjustment for the presence of comorbidities compared with standard death rate. This study showed that age is an important factor in PV and PF patients in Korea.

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Section: Discussionmentioning

confidence: 99%

Incidence and death rate of pemphigus vulgaris and pemphigus foliaceus in Korea: A nationwide, population‐based study (2006–2015)

Lee

et al. 2018

The Journal of Dermatology

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“…Stillbirths have been reported in four cases 6 ,. 8 , 10 , 18 The cause of the stillbirths was not clear, but high maternal titres of pemphigus antibodies of between 1 : 160 and 1 : 320 were found ( Table 1). In addition, the mothers had disease that was difficult to control, requiring high doses of corticosteroid (100–300 mg) with or without dapsone or azathioprine.…”

Section: Discussionmentioning

confidence: 99%

Neonatal pemphigus vulgaris associated with mild oral pemphigus vulgaris in the mother during pregnancy

Chowdhury

Natarajan

1998

British Journal of Dermatology

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We report a neonate with immunofluorescence-proven pemphigus vulgaris. The condition presented at birth with widespread skin erosions and ulceration of the oral mucosa. Histopathological and immunofluorescence studies confirmed pemphigus vulgaris. The mother had mild oral pemphigus vulgaris treated during pregnancy with topical corticosteroids. All the neonate's skin erosions had crust formation at day 2 but healed completely within 2 weeks.

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“…The literature review identified 51 original cases of neonatal AIBDs from 48 full‐text papers : 46 from the English‐language literature and 5 in other languages, which were translated. There was an increase in the number of reported cases over the decades.…”

Section: Resultsmentioning

confidence: 99%

Neonatal Autoimmune Blistering Disease: A Systematic Review

Zhao

Chiang

Murrell

2016

Pediatric Dermatology

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We aimed to better understand the pathogenesis, clinical features, prognosis, and treatment of neonatal autoimmune blistering diseases (AIBDs). We searched Medline, Embase, PubMed, Latin American and Caribbean Health Sciences Literature, and reference lists of identified articles. Inclusion criteria were articles published from 1946 to December 2014 in any language. Exclusion criteria were age greater than 4 weeks and no confirmed AIBD diagnosis. We identified 51 cases of neonatal AIBDs: 34 cases of pemphigus (31 pemphigus vulgaris [PV], 3 pemphigus foliaceus [PF]) and 17 cases of pemphigoid diseases (9 bullous pemphigoid [BP], 5 linear immunoglobulin A bullous dermatosis [LABD], 1 BP and LABD, 1 epidermolysis bullosa acquisita, 1 bullous systemic lupus erythematosus). Pemphigoid diseases had a higher male predominance (male:female ratio 4.6:1) than pemphigus (male:female ratio 1:1.06) (p = 0.004). Pemphigus had a higher proportion presenting at birth (79.4%) than pemphigoid diseases (29.4%) (p = 0.008). The most common sites involved were the trunk (63.0%), followed by the head and neck (60.9%). The mucosal membranes were involved in 32.6% of cases (27.6% in pemphigus, 41.6% in pemphigoid diseases). Only 33.3% used systemic therapy, and 75.5% achieved control within 3 weeks. Most PV, PF, and BP cases, but not LABDs, reported maternal disease. In pemphigus cases, 75.0% of mothers had active disease and 25.0% were in control. Pregnant women with PV, PF, and PG of any severity can passively transfer autoantibodies leading to neonatal AIBD. Pemphigoid diseases are more likely to present after birth and may be more male predominant. The presentation of LABDs may be different from that of all other AIBDs.

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Transplacental Transmission of Pemphigus

Cited by 60 publications

References 11 publications

Incidence and death rate of pemphigus vulgaris and pemphigus foliaceus in Korea: A nationwide, population‐based study (2006–2015)

Incidence and death rate of pemphigus vulgaris and pemphigus foliaceus in Korea: A nationwide, population‐based study (2006–2015)

Neonatal pemphigus vulgaris associated with mild oral pemphigus vulgaris in the mother during pregnancy

Neonatal Autoimmune Blistering Disease: A Systematic Review

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