Transplant-acquired food allergy: current perspectives

Hosakoppal, Shweta; Bryce, Paul J.

doi:10.2147/jaa.s136319

Cited by 25 publications

(17 citation statements)

References 59 publications

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“…Interestingly, 4 of these donors were under the age of 18. Donor‐derived food allergy has been described for at least 20 years, and in 1 review of previously reported cases the vast majority (>100 cases) were reported in liver recipients, presumably because of the persistence of hematopoietic stem cells preferentially in that organ 22,23 . In the DTAC series, lung and kidney‐pancreas (but not kidney alone) also developed peanut allergy, which is consistent with previous reports 22 …”

Section: Discussionsupporting

confidence: 87%

Ten years of donor-derived disease: A report of the disease transmission advisory committee

Kaul

Vece²,

Blumberg

et al. 2021

American Journal of Transplantation

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Despite clinical and laboratory screening of potential donors for transmissible disease, unexpected transmission of disease from donor to recipient remains an inherent risk of organ transplantation. The Disease Transmission Advisory Committee (DTAC) was created to review and classify reports of potential disease transmission and use this information to inform national policy and improve patient safety. From January 1, 2008 to December 31, 2017, the DTAC received 2185 reports; 335 (15%) were classified as a proven/probable donor transmission event. Infections were transmitted most commonly (67%), followed by malignancies (29%), and other disease processes (6%). Forty‐six percent of recipients receiving organs from a donor that transmitted disease to at least 1 recipient developed a donor‐derived disease (DDD). Sixty‐seven percent of recipients developed symptoms of DDD within 30 days of transplantation, and all bacterial infections were recognized within 45 days. Graft loss or death occurred in about one third of recipients with DDD, with higher rates associated with malignancy transmission and parasitic and fungal diseases. Unexpected DDD was rare, occurring in 0.18% of all transplant recipients. These findings will help focus future efforts to recognize and prevent DDD.

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Section: Discussionsupporting

confidence: 87%

Ten years of donor-derived disease: A report of the disease transmission advisory committee

Kaul

Vece²,

Blumberg

et al. 2021

American Journal of Transplantation

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“…This is not based upon fixed acupuncture points, as per meridian-based traditional body acupuncture. Curiously, Soliman's clinical correlations are also congruent with the phenomenon of liver transplant-acquired allergies and the passive transfer of IgE, not observed via transplant of other organs [26].…”

Section: Mechanism Of Saatmentioning

confidence: 60%

Effect of Soliman Auricular Allergy Treatment (SAAT) on IgE-mediated Reactions Due to Exposure to Mammalian Meat Oligosaccharide, Galactose-α-1,3-Galactose

Liebell¹

2020

AJBLS

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“…The prominent finding is the occurrence of an anaphylactic or sensitivity reaction in response to ingesting the food, most often peanuts, though reactions to other foods have been reported. These reactions can be transient and resolve over time; however, others report that these acquired food allergies remain a lifelong issue . Given this impact, it may be prudent to include this in donor screening and post‐transplant follow‐up.…”

Section: Donor Comorbiditiesmentioning

confidence: 99%

Review of the impact of donor characteristics on pediatric heart transplant outcomes

Conway

Ballweg

Fenton

et al. 2020

Pediatric Transplantation

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Heart transplantation (HTx) is a treatment option for end‐stage heart failure in children. HTx is limited by the availability and acceptability of donor hearts. Refusal of donor hearts has been reported to be common with reasons for refusal including preexisting donor characteristics. This review will focus on the impact of donor characteristics and comorbidities on outcomes following pediatric HTx. A literature review was performed to identify articles on donor characteristics and comorbidities and pediatric HTx outcomes. There are many donor characteristics to consider when accepting a donor heart. Weight‐based matching is the most common form of matching in pediatric HTx with a donor‐recipient weight ratio between 0.7 and 3 having limited impact on outcomes. From an age perspective, donors <50 years can be carefully considered, but the impact of ischemic time needs to be understood. To increase the donor pool, with minimal impact on outcomes, ABO‐incompatible donors should be considered in patients that are eligible. Other factors to be considered when accepting an organ is donor comorbidities. Little is known about donor comorbidities in pediatric HTx, with most of the data available focusing on infections. Being aware of the potential infections in the donor, understanding the testing available and risks of transmission, and treatment options for the recipient is essential. There are a number of donor characteristics that potentially impact outcomes following pediatric HTx, but these need to be taken into consideration along with their interactions with recipient factors when interpreting the outcomes following HTx.

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Transplant-acquired food allergy: current perspectives

Cited by 25 publications

References 59 publications

Ten years of donor-derived disease: A report of the disease transmission advisory committee

Ten years of donor-derived disease: A report of the disease transmission advisory committee

Effect of Soliman Auricular Allergy Treatment (SAAT) on IgE-mediated Reactions Due to Exposure to Mammalian Meat Oligosaccharide, Galactose-α-1,3-Galactose

Review of the impact of donor characteristics on pediatric heart transplant outcomes

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