Transplantatendothel und Hornhaut-Pachymetrie nach Nicht-Hochrisiko-Keratoplastik mit kurzzeit- oder langzeitkonserviertem Hornhautspendergewebe

Abstract

During the first year after PK, only a small decrease in endothelial cell density was observed in comparison with the 6-weeks finding. The storage method does not seem to affect the short-term changes of endothelial cell density. Further long-term studies are necessary to assess the clinical relevance of these observations.

Predictive donor factors for chronic endothelial cell loss after nonmechanical penetrating keratoplasty in a regression model

“…The goal of this study was to focus on the donor-associated determinants of the idiopathic endothelial cell loss after nonmechanical penetrating keratoplasty. Reports in the literature indicate that the method of preservation of the graft does not effect the chronic endothelial cell loss after keratoplasty [12,21,22,25], whereas the epithelium may be altered after an excessive storage time in dextran-added organ culture medium [31] . In accordance with these results we found that there was no difference between organ-cultured and short-term-preserved donor corneas in the total population as well as in any diagnosis group.…”

“…Most of the studies available in the literature describe the corneal endothelial cell loss in a cross-sectional fashion after PK [6,7,8,9,12,13,20,21,30,34]. However, the results of these studies may not be indicative for the chronic endothelial cell loss in the long-term follow-up, because the inter-individual scatter between patients in the early postoperative stage is too high to derive consistent results.…”

Corneal endothelial cell loss after nonmechanical penetrating keratoplasty depends on diagnosis: a regression analysis

“…The exact benchmark for corneal decompensation and opacification of the stroma due to inadequate dehydration of the cornea is groups in the present study. Reports in the literature indicate that the method of graft preservation does not affect the chronic endothelial cell loss after keratoplasty [11,24,26,29].…”

“…Most of the studies available in the literature describe the corneal endothelial cell loss in a cross-sectional fashion after PK [5,6,7,8,11,13,24,33,37]. However, the results of these studies may not be indicative of the chronic endothelial cell loss in the long term, because the interindividual scatter between patients in the early postoperative stage is too high to derive consistent results.…”

Efficacy and Safety of Corneal Transplantation Using Corneas from Foreign Donors versus Domestic Donors: A Prospective, Randomized, Controlled Trial

“…Secondary, the reduced antigen of the low temperature preserved corneas was another affecting factor [15]. Nguyen et al [16] indicated that graft failure rate of long-term preserved donor corneas was lower compared to short-term-preserved corneas when PKP was performed. The findings of our study showed that the rate of immunologic rejection and graft clarify were comparable in both groups throughout the follow-up period.…”