Transplantation for alcoholic liver disease

What determines the natural history of recurrent hepatitis C after liver transplantation?

“…None of the studies, which have looked at predictive variables of worse histological and/or clinical outcome have found that a history of significant alcohol consumption pre-transplantation was associated with a more aggressive disease following transplantation [1,9]. Preliminary data from our centre suggest that patients with mixed aetiologies have a histological outcome post-transplantation that is worse than that seen in patients undergoing transplantation for HCV alone; based on protocol liver biopsies, only 25% of patients transplanted for mixed aetiologies had normal or minimally abnormal liver biopsies after a prolonged follow-up compared to 59% in the HCV (C) group [37]. More data are needed to address this question.…”

Indications and Contraindications for Liver Transplantation

“…A patient with ALD who is abstinent for a period of at least 3–6 months and who has had an evaluation with a psychiatrist is listed for transplantation if he has a CTP score of ≥7, portal hypertensive bleed, or an episode of spontaneous bacterial peritonitis [18]. These patients may have a concurrent infection with hepatitis B or C virus which needs evaluation.…”

Guía clínica de evaluación de pacientes con conductas adictivas para trasplante hepático

“…En caso de recaída durante el seguimiento inicial o una vez aceptado el paciente para trasplante y puesto en lista de espera, éste se mantendrá excluido temporalmente de la lista un mínimo de 6 meses, realizándose controles y reevaluando el caso [25][26][27] .…”