Transplantation of adipose‐derived mesenchymal stem cells into a murine model of passive chronic immune thrombocytopenia

Abstract

These findings constitute the first experimental evidence that ADSCs are efficacious in improving PLT levels and reducing the related Th cytokines mediating proinflammatory response in ITP mice, which may provide a scientific basis for using ADSCs as a new therapy for ITP.

Thalidomide corrects impaired mesenchymal stem cell function in inducing tolerogenic DCs in patients with immune thrombocytopenia

“…42 More importantly, these findings have provided the rationale for the use of healthy donorderived MSCs in ITP patients 43 and in the murine model. 44 In this study, we demonstrated that MSCs from ITP patients had a lower proliferative capacity, which was consistent with previous reports. 10 When treated with THD, their apoptosis decreased significantly and more cells entered into S 1 G2 phase.…”

Activated platelet-rich plasma improves adipose-derived stem cell transplantation efficiency in injured articular cartilage

“…ADSCs are considered a suitable autologous cell source. Moreover, ADSCs have been used to treat many diseases such as liver fibrosis [19], nerve defects [20-22], ischemia [23,24], skeletal muscle injury [25], passive chronic immune thrombocytopenia [26], and infarcted myocardium [27] in animals; and systemic sclerosis in human [28,29]. …”

Chondrogenic differentiation of human adipose mesenchimal stem cells: Influence of a biomimetic gelatin genipin crosslinked porous scaffold

“…These cells may easily be obtained in the autologous setting, and they proliferate rapidly in culture (Sekiya et al, ). Recently, many studies have indicated that human adipose‐derived stem cells (hADSCs) can easily be obtained from liposuction waste or arthroscopy, and maintained in a stable undifferentiated state during in vitro expansion (Fraser et al, ; Xiao et al, ; Zhang et al, ). These cells have the capacity to differentiate into cartilage and other different lineages.…”