Transplantation of bone marrow-derived mesenchymal stem cells facilitates epithelial repair and relieves the impairment of gastrointestinal function in a rat model of enteritis

Jiang, Haiyan; Wang, Beibei; Tong, Jia-Zhao; Yu, Bo; Zhang, Yonghong; Liu, Bing-Rong; Zhu, Fang; Jin, Shizhu

doi:10.1016/j.clinre.2014.07.015

Cited by 3 publications

(2 citation statements)

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“…Rectal bleeding was assigned a score of 0, which indicated a negative haematological test, a positive haematological test was assigned a score of 2, and general haemorrhaging was assigned a score of 4. The individual scores were added and divided by 3 to obtain a standard score of 0–4 for each group (Qu et al, 2015). Data were obtained and compared between the GRd treatment and control groups.…”

Section: Resultsmentioning

confidence: 99%

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Ginsenoside Rd therapy improves histological and functional recovery in a rat model of inflammatory bowel disease

Yang

Liang

Lin

et al. 2020

Phytotherapy Research

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Ginsenoside Rd (GRd) is a biologically active component of ginseng that stimulates the proliferation of endogenous stem cells. The objective of our research was to evaluate the utility of GRd in gastrointestinal mucosal regeneration in a rat model of inflammatory bowel disease (IBD) and to clarify whether GRd exerts its pharmacological effects by modulating endogenous intestinal stem cells. The IBD rat model was established via subcutaneous injection of indomethacin, and 10, 20, or 40 mg/kg GRd or an equal volume of physiological saline was then administered orally to rats in different groups every day for seven consecutive days. We observed that GRd treatment, especially 20 mg/kg GRd, significantly reduced indomethacin-induced damage compared with that in the control group. By measuring the mRNA and protein levels of the intestinal stem cell markers Bmi and Msi-1 and the intestinal epithelial cell marker CDX-2 as well as by double-labelling these markers with 5-bromo-2-deoxyuridine (BrdU), we inferred that GRd could stimulate the proliferation and differentiation of endogenous intestinal stem cells in IBD model rats, leading to improved recovery of intestinal function.

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Section: Resultsmentioning

confidence: 99%

“…score of 0-4 for each group (Qu et al, 2015). Data were obtained and compared between the GRd treatment and control groups.…”

Section: T a B L Ementioning

confidence: 99%