Transplantation of Human Embryonic Stem Cells in Patients with Multiple Sclerosis and Lyme Disease

Abstract

Case seriesPatient: Male, 42 • Female, 30Final Diagnosis: Human embryonic stem cells showed good therapeutic potential for treatment of multiple sclerosis with lyme diseaseSymptoms: Fatigue • weakness in limbsMedication: —Clinical Procedure: Human embryonic stem cells transplantationSpecialty: TransplantologyObjective:Rare diseaseBackground:Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease in which the myelin sheath of nerve cells is damaged. It can cause delayed neurologic symptoms similar to those seen in Lyme disease (LD) patients. Thymus derived T-cells (myelin reactive) migrate to the blood brain barrier and stimulate an inflammatory cascade in the central nervous system. Cell based therapies play an important role in treating neurological diseases such as MS and LD.Case Report:Human embryonic stem cell (hESC) therapy was used to treat two patients with both MS and LD. The hESCs were administered via different routes including intramuscular, intravenous, and supplemental routes (e.g., deep spinal, caudal, intercostal through eye drops) to regenerate the injured cells. Both the patients showed remarkable improvement in their functional skills, overall stamina, cognitive abilities, and muscle strength. Furthermore, the improvement in the patients’ conditions were assessed by magnetic resonance tractography and single photon emission computed tomography (SPECT).Conclusions:Therapy with hESCs might emerge as an effective and safe treatment for patients with both MS and LD. Well-designed clinical trials and follow-up studies are needed to prove the long-term efficacy and safety of hESC therapy in the treatment of patients with MS and LD.

Stem cell therapies: a new era in the treatment of multiple sclerosis

“…In another investigation, two patients with concurrent diagnoses of MS and Lyme Disease (LD) exhibited significant improvements in functional abilities, endurance, cognitive function, and muscle strength following hESC therapy, as assessed by diffusion tensor imaging and single-photon emission computed tomography. These outcomes suggest the efficacy and safety of hESC therapy for patients with MS and LD (161). However, the current body of evidence remains limited, underscoring the need for comprehensive clinical trials to confirm the long-term efficacy and safety of hESC therapy in MS. Research in this area continues to face various technical and ethical challenges, including issues related to the sourcing of ESCs and controlling their differentiation.…”

Current state of stem cell research in non-human primates: an overview

“…When it comes to treating MS and lyme disease (LD), both intramuscular (IM) and intravenous (IV) injections of human ESCs have resulted in significant improvements in patients’ skills, overall stamina, cognitive abilities, and muscle strength [ 121 ]. This further confirms the safety and efficacy of the treatment.…”

Stem Cell-Based Therapeutic Strategies in Diabetic Wound Healing

“…An ex vivo induction of human ESCs into basal keratinocytes was evidenced to be fully functional and enabled the construction of a pluristratified epidermis to facilitate wound healing in immunodeficient nude mice [ 80 ]. Furthermore, ESCs were also demonstrated to be safe and clinically beneficial (at least symptomatic improvements) in variant diseases including spinal cord injury, type 2 diabetes mellitus, emphysema, multiple sclerosis, and Lyme disease, without any adverse events being reported [ 81 , 82 , 83 , 84 ].…”