Transplantation of Human Vitreous

Cutler, Norman L.

doi:10.1001/archopht.1946.00890200630002

Cited by 23 publications

(10 citation statements)

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“…Many years ago, some authors described the first attempt to transplant vitreal tissue [110–112]. They observed that, if correctly stored, the vitreous body could maintain its structure and also its enzymatic properties, as described in the literature [8, 9, 11].…”

Section: Experimental Substitutesmentioning

confidence: 99%

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Vitreous Substitutes: The Present and the Future

Donati

Caprani

Airaghi

et al. 2014

BioMed Research International

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Vitreoretinal surgery has advanced in numerous directions during recent years. The removal of the vitreous body is one of the main characteristics of this surgical procedure. Several molecules have been tested in the past to fill the vitreous cavity and to mimic its functions. We here review the currently available vitreous substitutes, focusing on their molecular properties and functions, together with their adverse effects. Afterwards we describe the characteristics of the ideal vitreous substitute. The challenges facing every ophthalmology researcher are to reach a long-term intraocular permanence of vitreous substitute with total inertness of the molecule injected and the control of inflammatory reactions. We report new polymers with gelification characteristics and smart hydrogels representing the future of vitreoretinal surgery. Finally, we describe the current studies on vitreous regeneration and cell cultures to create new intraocular gels with optimal biocompatibility and rheological properties.

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Section: Experimental Substitutesmentioning

confidence: 99%

“…The implanted tissue showed a degradation time on the host, with a low inflammatory reaction and interesting surgical results on 40% of patients. Cataract, glaucoma, and more severe adverse events until ocular atrophy were described [110–112]. …”

Section: Experimental Substitutesmentioning

confidence: 99%

Vitreous Substitutes: The Present and the Future

Donati

Caprani

Airaghi

et al. 2014

BioMed Research International

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“…The requirement for transplantation was explained by the particular chemical properties of the vitreous, as it contains approximately 99% of water having a viscosity 20 to 200 times higher than water. 12 Moreover, it was known that the fibrillar structure of the vitreous once destroyed cannot be replaced or regenerated. 14 The researchers aimed to restore the chemical composition of the vitreous rather than the physical properties; the rationale for this approach was the belief that if the normal chemical composition would not be maintained, it would lead to postoperative irritation and intraocular pressure rise.…”

Section: Resultsmentioning

confidence: 99%

“…14 The researchers aimed to restore the chemical composition of the vitreous rather than the physical properties; the rationale for this approach was the belief that if the normal chemical composition would not be maintained, it would lead to postoperative irritation and intraocular pressure rise. 12 For example, it was reported that substitution of the vitreous with physiological saline solution lacks the healing power, and particularly the bactericidal and reabsorbent properties of a human vitreous. 15 Within the procedure of vitreous transplantation, across the scleral incision, two opposite mattress sutures were usually placed (Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Early Descriptions of Vitreous Surgery

Grzybowski

Kanclerz²

2021

Retina

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Background: Vitreoretinal surgical techniques have evolved during the last decades because of the development and evolution of pars plana vitrectomy. The introduction of modern vitrectomy is credited to Robert Machemer . The aim of this review is to characterize the early developments of vitreous removal.Methods: We used the PubMed web platform to search the terms: complications of cataract surgery, vitrectomy, vitreous body, vitreous humor, vitreous humour, vitreous tap, and vitreous transplantation. Other publications were also considered as a potential source of information when referenced in relevant articles.Results: The first description of vitreous removal for treatment of eye disorders dates the 17th century; it was conducted by a Dutch surgeon Anton Nuck (1650-1692) in a case of hydrophthalmia. In English literature, the first description of vitrectomy is attributed to the American surgeon John Collins Warren (1778-1856). This method was implemented in the spontaneous dislocation of the crystalline lens. As the fibrillar structure of the vitreous once destroyed could not be regenerated, the researchers aimed to restore the chemical composition of the vitreous. For several decades, vitreous transplantation was performed for the treatment of vitreous hemorrhages and retinal detachment.Conclusion: Although the achievements of vitreoretinal surgery preceding Machemer's inventions are uncommonly reported, they have contributed to the concept and understanding of the treatment modalities.RETINA 41:1364-1372, 2021V itreoretinal surgical techniques have evolved during the last decades because of the development and evolution of pars plana vitrectomy. The introduction of modern vitrectomy is credited to Robert Machemer (1933Machemer ( -2009. 1 The most important consecutive developments include smaller gauge instrumentation, higher cut speed, improved illumination systems, better microscopes, and the use of perfluorocarbon liquids. These well-known improvements have increased the efficacy and safety of contemporary vitrectomy. The variety of conditions that can be successfully treated with vitreoretinal surgery has greatly expanded and includes complications of diabetic retinopathy, vitreous opacities, epiretinal membranes, macular holes, and retinal detachments. Although the achievements of vitreoretinal surgery preceding Machemer's inventions are uncommonly reported, they have contributed to the concept and understanding of the treatment modalities. AimThe aim of this study is to characterize the early developments of vitreous removal. Focus was placed From the

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“…Attempts to perform premechanized vitreous surgery were made through limbal and pars plana approaches using vitreous aspiration with or without replacement; the former used saline, donor vitreous, air, gas, silicone oil, or collagen to insufflate the vitreous cavity and strip PVR bands or membranes. [1][2][3][4][5][6][7][8][9][10][11][12] Simultaneously, vitreoretinal membrane division/cutting was employed using intravitreal knives, punches, scissors, and balloons. [13][14][15][16]…”

Section: A Look At the Pastmentioning

confidence: 99%

Surgery as the Primary Management of Proliferative Vitreoretinopathy

Aaberg

2010

Arch Ophthalmol

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lthough attempts were made ot reattach retinas using proliferative vitreoretinopathy by various techniques before the 1970s, it was the development and subsequent refinement of closed-eye, mechanized pars plana vitrectomy that initiated the rapid rise in the surgical success rate. This article presents a personal history of the milestone accomplishments that facilitated the strong possibility of success that patients with proliferative vitreoretinopathy can now anticipate. Currently, various gasses, chemical compounds, and pharmaceutical agents serve adjunctively to advance surgical techniques with the expectation that they may be the primary curative procedure in the future. As in the past, what is unconventional today may be common tomorrow.

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Transplantation of Human Vitreous

Cited by 23 publications

References 1 publication

Vitreous Substitutes: The Present and the Future

Vitreous Substitutes: The Present and the Future

Early Descriptions of Vitreous Surgery

Surgery as the Primary Management of Proliferative Vitreoretinopathy

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