Transplantation of kidneys from paediatric DCD donors: a comparison with DBD donors

Abstract

Paediatric DCD kidneys represent a valuable source of donor kidneys that has not been fully utilized. Although transplantation of paediatric DCD kidneys is associated with a higher risk of graft failure than transplantation of paediatric DBD kidneys, results are comparable with adult donors. We therefore conclude that paediatric DCD kidneys can be safely added to the donor pool.

Pediatric Donation After Circulatory Determination of Death

“…Transplant outcomes are based on limited data and show a higher prevalence of delayed kidney graft function but good short-and mediumterm graft function and patient survival. There is no significant difference in longer term kidney outcomes compared with NDD (39,40,83). Long-term liver outcomes also seem to be similar with those from NDD donors, although data are lacking.…”

“…Recipient survival ranged from 100% at 1 year (58,99) to 93% at 3 years (39). There was no significant long-term outcome difference in graft and patient survival compared with NDD (39,40,83). pDCDD Liver Transplantation.…”

“…Nine hundred one kidney transplants were reported in 11 retrospective studies (39,40,58,60,83,91,(94)(95)(96)(97)99), with the majority of the sample from three database reviews (39,40,83) and one case series (60). Delayed graft function ranged from 23% to 48% (40,58,83,99) and is significantly higher when compared with NDD kidneys. Graft survival ranged from 92.4% to 100% (32)(33)(34) at 1 year, 71% (39) to 85.6% (40) at 3 years, and 80.7% at 5 years (40).…”

Comparison of outcomes of kidney transplantation from donation after brain death, donation after circulatory death, and donation after brain death followed by circulatory death donors

“…It has been reported that DGF rate is much higher in DCD kidney transplant compared to DBD kidney transplant . However, the DGF rate in DBCD kidney transplant has not been published before.…”

Kidney donation after circulatory death: current evidence and opportunities for pediatric recipients

“…A study from the Netherlands in 2013 showed that renal allograft survival in kidney transplantation was slightly worse for pediatric DCD donors compared to pediatric DBD donors, but that these results were comparable to adult DCD donors [19]. This suggests that pediatric DCD donors could be considered in a similar way to adult DCD donors, in order to expand the potential donor pool.…”