2009
DOI: 10.1097/sla.0b013e31818a1543
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Transplantation of Monocyte-Derived Hepatocyte-Like Cells (NeoHeps) Improves Survival in a Model of Acute Liver Failure

Abstract: Hepatocyte transplantation is a practicable and successful treatment option in case of liver insufficiency because implantation of NeoHeps or primary rat hepatocytes had an improving effect on survival. The promising data of the present study warrants further analysis to elucidate the role of NeoHeps in treatment of acute postoperative liver failure to a greater extent.

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Cited by 25 publications
(15 citation statements)
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“…But the transplantation rejective response is a formidable problem after liver transplantation, especially acute rejection which is the main cause of early dysfunction and transplantation failure [7]. The incidence rate of acute rejection after liver transplantation is up to 50% to 70% [8]. The acute rejection after the organ transplantation is mainly caused by the activation of the immune system in the host.…”
Section: Introductionmentioning
confidence: 99%
“…But the transplantation rejective response is a formidable problem after liver transplantation, especially acute rejection which is the main cause of early dysfunction and transplantation failure [7]. The incidence rate of acute rejection after liver transplantation is up to 50% to 70% [8]. The acute rejection after the organ transplantation is mainly caused by the activation of the immune system in the host.…”
Section: Introductionmentioning
confidence: 99%
“…Successful systemic injection relies on homing of the injected cells to the target tissue/organ 15, 16 . Homing of stem cells subsequent to systemic injection has been shown in a variety of highly vascular tissues, including bone marrow, myocardium 17 , and liver 18 . Systemic administration of cells entails passage through pulmonary capillaries with potential risk of entrapment in the microvasculature 19 .…”
Section: Delivery Strategiesmentioning
confidence: 99%
“…Tissue engineering After systemic application in animal models of hepatic intoxication and partial hepatectomy, myocardial infarction, nephropathy, cerebral ischemia, lung injury, lung fibrosis, and local irradiation, stem cells are enriched in injured tissue and partially differentiated into tissue-specific cell types [2,[17][18][19][20][21][22][23][24][25][26]. There have also been systemic applications of mesenchymal stem cells in humans with beneficial effect in graft-versus-host disease or osteogenesis imperfecta [27,28].…”
Section: Cell Therapymentioning
confidence: 99%