Transplantation of oral benign tumors to nude mice.

Abstract

Abstract:Human benign tumors were transplanted to 31 nude mice. Tissues from 6 cases of ameloblastoma and 1 case of pleomorphic adenoma were transplanted to the subcapsular space of the kidney and the subcutaneous space of normal 8-week-old KSN male nude mice. Animals were sacrificed periodically and serial sections were made for histological examination. Transplantation was successful in 3 cases of solid type ameloblastoma and in the case of pleomorphic adenoma. In cystic type ameloblastoma, the transplants gradually became smaller and disappeared in 2 months. These results suggest that several conditions are indispensable for successful transplantation. The morphological characteristics of transplanted tumor tissues were basically similar to those of the primary tumors.