Transplantation of polymer-encapsulated fetal hippocampal cells into ischemic lesions of adult rat hippocampus

Transplantation of human fetal brain cells into ischemic lesions of adult gerbil hippocampus

“…The host's environmental cues, such as growth factors and extracellular matrix proteins, as well as the grafted cells' receptors for these factors, probably play major roles in cell survival and differentiation posttransplantation. 28,32 The fact that both vehicle-and cell-injected transplantation sites shared identical needle track scars is similar to findings in a previously published article on intracerebral transplantation. 15 The nature and distribution of astroglia and developmentally regulated extracellular matrix molecules between donor and host regions may affect the survival of the transplanted cells in the scarred area.…”

“…Most studies have been performed in adult rats, in which focal or transient occlusion of the middle cerebral artery is used. 9 Allogeneic fetal transplanted cell types have included the following: striatal cells, 10 hippocampal cells, 17,24,32,33 and cortical cells. 16 The transplanted fetal cells have been demonstrated to survive and integrate with the host tissue and to reduce the ischemiarelated behavioral deficits in the short term.…”