Transplantationsversuche mit Hydra

Wetzel, Georg

doi:10.1007/bf02976210

Cited by 22 publications

(4 citation statements)

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“…Die im Sommer 1895 publicirten ,Transplantationsversuche an Hydra,, yon G. WETZEL (99) zeigten, dass die Transplantation bei unserem auBerordentlich regenerationsfiihigen SiiBwasserpolypen leicht zu bewerkstelligen sei.…”

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Transplantationsversuche an Lumbriciden

Joest

1897

Archiv für Entwickelungsmechanik der Organismen

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unclassified

Transplantationsversuche an Lumbriciden

Joest

1897

Archiv für Entwickelungsmechanik der Organismen

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“…Hydra has inspired Alan Turing to his seminal reaction-diffusion principle and, indeed, numerous grafting experiments [2][3][4] could be interpreted by postulating local activator and global inhibitor gradients as proposed by him [5] and elaborated by Gierer & Meinhardt [6,7]. Despite great success (e. g. explanation of the existence of a minimal tissue size for regeneration), the gradient-forming molecules still have not been clearly identified [8].…”

Section: Introductionmentioning

confidence: 99%

Fluctuations and differential contraction during regeneration ofHydra vulgaristissue toroids

et al. 2013

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We studied regenerating bilayered tissue toroids dissected from Hydra vulgaris polyps and relate our macroscopic observations to the dynamics of force-generating mesoscopic cytoskeletal structures. Tissue fragments undergo a specific toroid-spheroid folding process leading to complete regeneration towards a new organism. The time scale of folding is too fast for biochemical signalling or morphogenetic gradients, which forced us to assume purely mechanical self-organization. The initial pattern selection dynamics was studied by embedding toroids into hydro-gels, allowing us to observe the deformation modes over longer periods of time. We found increasing mechanical fluctuations which break the toroidal symmetry, and discuss the evolution of their power spectra for various gel stiffnesses. Our observations are related to singlecell studies which explain the mechanical feasibility of the folding process. In addition, we observed switching of cells from a tissue bound to a migrating state after folding failure as well as in tissue injury. We found a supra-cellular * This paper is dedicated to Malcolm Steinberg.

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“…on the Smaller Piece. In one of the experiments made by WE'vz~rJ (10), the foot ends of two Hydra g'risea were removed by transverse cuts, and the two aboral surfaces of the polyps were then grafted together. Subsequently the head of one component of the graft was cut off just back of the circle of tentacles.…”

Section: B Grafting To Determine the Influence Of The Largermentioning

confidence: 99%