Transplants from the Same Donor

Vesole, DH

doi:10.7326/0003-4819-116-3-269

Cited by 7 publications

(3 citation statements)

References 2 publications

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“…In addition, maintenance of hemodialysis during the neutropenic state of HSCT can increase the risk of fatal infection. In contrast, successful cases of BMT in kidney transplanted state without deterioration of renal function or severe infection have been reported (11, 12). Therefore, we elected to perform KT rather than continue dialysis treatment.…”

Section: Discussionmentioning

confidence: 99%

Kidney Transplantation in a Patient with End Stage Renal Disease after Complete Remission of Acute Promyelocytic Leukemia

et al. 2012

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In general, a 2-yr disease-free duration is recommended before kidney transplantation (KT) in end-stage renal disease (ESRD) patients who also have acute leukemia. However, the optimal disease-free interval has not been specified for all subtypes of acute leukemia. Among these subtypes, acute promyelocytic leukemia (APL) shows a favorable prognosis and low relapse rate compared to other types of leukemia. We here report KT after complete remission (CR) of APL in an ESRD patient. Irreversible kidney injury developed in a 23-yr-old man with APL. First, we induced CR and subsequently performed KT 7 months after the achievement of CR. The patient's clinical course after KT was favorable, without allograft rejection or relapse of APL up to1 yr after KT. On the basis of our clinical experience, it is suggested that a long wait may not be necessary before KT in patients with ESRD and APL.

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Section: Discussionmentioning

confidence: 99%

Kidney Transplantation in a Patient with End Stage Renal Disease after Complete Remission of Acute Promyelocytic Leukemia

et al. 2012

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“…Graft rejection following mixed solid organ/ bone marrow grafts has not been reported. The use of allogeneic hematopoietic transplantation for tolerance induction of solid organ transplants has been limited by the toxicity of the transplant preparative regimen, graft vs. host disease, and a high rate of treatment-related mortality associated with bone marrow transplant procedures [8][9][10][11][12][13][14]. Recently, new nonmyeloablative bone marrow transplant preparative regimens have been shown to induce complete or mixed hematopoietic chimerism [15,16].…”

Section: Discussionmentioning

confidence: 99%

Discontinuation of immunosuppression for prevention of kidney graft rejection after receiving a bone marrow transplant from the same HLA identical sibling donor

Gajewski

Ippoliti

et al. 2002

American J Hematol

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Induction of tolerance in solid organ transplant recipients has been a long sought goal so that patients will not need lifelong immunosuppression. In this case report we review a patient who received a kidney transplant from an HLA matched related sibling and developed acute leukemia as a consequence of her immunosuppression. The patient was then treated with an allogeneic bone marrow transplant from her kidney donor. After the bone marrow transplant, all immunosuppression therapy for graft rejection and graft versus host disease was stopped. Six months after the bone marrow transplant, the patient's kidney function had no deterioration as a consequence of stopping immunosuppression. This illustrated that a combined solid organ/bone marrow transplant can help to induce tolerance. In fact, the tolerance to the bone marrow transplant for prevention of graft versus host disease may have been accomplished by the prior kidney transplant. Am. J. Hematol. 71:311-313, 2002.

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“…The immunologic impact of performing an HCT from the same donor as the previous SOT has been less well characterized. Two reports, however, described severe graft-versus-host disease (fatal in 1 case) in 2 patients who received an HLA-matched related donor HCT years after a kidney transplant from the same donor, raising the possibility that graft-versus-host alloreactivity was relatively unopposed in these patients who had achieved host-versus-graft tolerance [14,15]. Another more theoretical consequence of HCT after SOT is a "graft-versus-graft effect" when there is histoincompatibility between the solid organ and the patient and the hematopoietic graft and the organ.…”

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confidence: 99%

Intersection of Hematopoietic Cell and Solid Organ Transplantation: Lessons Learned and Unanswered Questions

Spitzer

2015

Biology of Blood and Marrow Transplantation

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Transplants from the Same Donor

Cited by 7 publications

References 2 publications

Kidney Transplantation in a Patient with End Stage Renal Disease after Complete Remission of Acute Promyelocytic Leukemia

Kidney Transplantation in a Patient with End Stage Renal Disease after Complete Remission of Acute Promyelocytic Leukemia

Discontinuation of immunosuppression for prevention of kidney graft rejection after receiving a bone marrow transplant from the same HLA identical sibling donor

Intersection of Hematopoietic Cell and Solid Organ Transplantation: Lessons Learned and Unanswered Questions

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