Effective leadership in fast-changing environment necessitates a wide range of skills and competencies. The theory of Multiple Intelligences (MI) challenges the traditional conception of intelligence as a single, fixed characteristic. People have distinct forms of intelligence that may be nourished and developed through time. MI can assist leaders in adapting to change, building diverse and inclusive teams, and driving innovation. The leadership of the twentieth century witnessed a shift from one type of intelligence to another due to changing societal needs. Much previous research has attempted to draw out the relationship between MI and leadership performance. This chapter reviews the definitions and models in the field of MI and the connection between MI and leadership. The chapter highlights the leadership shift over time and examples of successful MNCs and SMEs resulting from entrepreneurial leadership in the context of multiple intelligence.