Transport and Control of Manganese Ions in the Central Nervous System

Mechanisms of environmental chemical-induced apoptosis in dopaminergic cells: critical roles of protein kinase C-delta and relevance to Parkinson's disease

“…Upon inhalation, Mn is absorbed into blood from lungs and binds to cationic carrier proteins, such as transferrin (Tf), albumin and divalent metal transporter-1 (DMT-1), and then is transported to various tissues including brain (Egyed and Wood, 1996;Davis et al, 1998;Aposhian et al, 1999). Free Mn 2+ , Tf bound Mn 3+ , and DMT-1 bound Mn 2+…”