Transport Distraction Osteogenesis With Recombinant Human Bone Morphogenic Protein-2 for Large Calvarial Defect Reconstruction

Song, Seung Yong; Yun, In Sik; Kim, Chung Hun; Woo, Dae Gon; Kim, Yong Oock

doi:10.1097/scs.0000000000000672

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Cited by 3 publications

(1 citation statement)

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“…There is growing evidence of the reliability of applying bone transport DO experimentally in the management of calvarial defects in animals. Song et al 17 demonstrated the effectiveness and the promising results of bone regeneration (clinically, histologically, and using 3D CT) using transport DO combined with recombinant human bone morphogenic protein-2 in dog models with large calvarial defects.…”

Section: Discussionmentioning

confidence: 99%

Bone Transport Distraction Osteogenesis in the Reconstruction of Pediatric Posttraumatic Calvarial Defects

Elbanoby

Aly

Abdelfattah

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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Section: Discussionmentioning

confidence: 99%

Bone Transport Distraction Osteogenesis in the Reconstruction of Pediatric Posttraumatic Calvarial Defects

Elbanoby

Aly

Abdelfattah

et al. 2019

Plastic and Reconstructive Surgery - Global Open

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Supramolecular self-assembling peptides to deliver bone morphogenetic proteins for skeletal regeneration

Chen

Hsu

Stupp

2020

Bone

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Off-Label Use of Bone Morphogenetic Protein 2 in the Reconstructions of Mandibular Continuity Defects

Oliveira

Gorla

Gabrielli

et al. 2017

Journal of Craniofacial Surgery

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This paper describes 3 patients of off-label use of bone morphogenetic protein 2 (rhBMP-2) in the reconstruction of mandibular continuity defects. In the first patient, rhBMP-2 was associated with iliac crest bone graft for late mandibular reconstruction after resection of osteosarcoma. In the 2 other patients, rhBMP-2 was used alone. In 1 patient the mandibular continuity defect was due to resection for treatment of osteomyelitis and in the other patient a continuity defect was created by unsuccessful osteogenic distraction for correction of mandibular hypoplasia. Despite the good results in those patients, the off-label use of rhBMP-2 is associated with increased rate of complications, so more studies are needed to assess the predictability of the use of rhBMP-2 in mandibular continuity defects. Therefore, at the moment the off-label use of rhBMP-2 should be restricted to complicated bone defects in which the conventional alternatives of reconstruction were unsuccessful.

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Transport Distraction Osteogenesis With Recombinant Human Bone Morphogenic Protein-2 for Large Calvarial Defect Reconstruction

Abstract: TDO with an internal distraction device delivering rhBMP-2 can enhance bone regeneration of large calvarial defects in a dog model. These results suggest the potential for human clinical testing of TDO combined with rhBMP-2.

Cited by 3 publications

References 36 publications

Bone Transport Distraction Osteogenesis in the Reconstruction of Pediatric Posttraumatic Calvarial Defects

Bone Transport Distraction Osteogenesis in the Reconstruction of Pediatric Posttraumatic Calvarial Defects

Supramolecular self-assembling peptides to deliver bone morphogenetic proteins for skeletal regeneration

Off-Label Use of Bone Morphogenetic Protein 2 in the Reconstructions of Mandibular Continuity Defects

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