There is a substantial body of research that recognises the importance of analysing regional characteristics in employment and labour relations that occur in a given geographical context. However, this phenomenon has been scarcely studied from a spatial approach. This article uses a spatio-temporal panel data model to examine the spatial interactions between the gender employment gap and, some labour and socioeconomic characteristics of 727 municipalities of Andalusia, Spain, for the period 2012–2016. The results show that due to spatial diffusion mechanisms, a spatial spillover effect occurs in both the gender gap in employment and in some of the labour and socioeconomic characteristics considered. These findings may be extended to other geographic areas and can be of use for the implementation of regional policies aimed at narrowing the gender employment gap. JEL Codes: R10, J16, E24