Transport of 1,5-anhydro-D-glucitol into insulinoma cells by a glucose-sensitive transport system

Yamanouchi, Toshikazu; Ogata, Nobuyuki; Yoshimura, Tomoe; Inoue, Takato; Ogata, Eri; Kawasaki, Terukazu; Kashiwabara, Akiko; Muraoka, Hirono

doi:10.1016/s0304-4165(00)00025-8

Cited by 9 publications

(3 citation statements)

References 44 publications

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“…In our study, there were no significant changes in 1,5-AG levels between the baseline and either 30 min or 60 min, but there were significant increases at 90 min, 120 min, and 180 min. The mechanism responsible for the increases may be the movement of 1,5-AG from the intracellular space to the extracellular space after a glycemic load, and a membrane transport system has been hypothesized [19][20][21][22][23]. When 1,5-AG is measured during routine checkups, references…”

Section: Discussionmentioning

confidence: 99%

Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests

et al. 2011

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The resulTs of recent studies indicate that postprandial hyperglycemia may be an independent risk factor for the development of macrovascular complications [1,2]. Although tight glycemic control is important to prevent complications of diabetes [3][4][5], many patients who are well controlled based on their HbA1c values have post-challenge hyperglycemia in oral glucose tolerance tests (OGTTs) [6]. 1,5-Anhydroglucitol (1,5-AG), a major 6-carbon dietary monosaccharide, is thought to reflect daily glycemic excursions, especially in patients Endocrine Journal 2011, 58 (1), [13][14][15][16][17] Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests Abstract. Since there is increasing evidence that postprandial hyperglycemia is a risk factor for the development of macrovascular complications, it is important to predict postprandial hyperglycemia in the early stages of glucose intolerance, and routine medical checkups provide a good opportunity to do so. The aim of this study was to evaluate the usability of 1,5-anhydroglucitol (1,5-AG) in routine medical checkups. The subjects were 77 Japanese men who participated in a routine medical checkup. First, we performed 75 g oral glucose tolerance tests (OGTTs), and examined the changes in glucose and 1,5-AG levels measured at 0, 30, 60, 90, 120, and 180 minutes (min). 1,5-AG levels did not significantly change until 90 min after the glucose load. Second, a linear regression analysis showed an inverse correlation between the 2-hour postchallenge glucose (2h-PG) and baseline 1,5-AG levels during the OGTT (P = 0.001, r 2 = 0.13), and the correlation was still significant after adjustment for age (2h-PG = 170 + 0.83 × (age in years) -3.23 × (1,5-AG), P = 0.002, adjusted r 2 = 0.12).Finally, to investigate the test characteristics of 1,5-AG levels as a predictor of a 2h-PG level ≥200 mg/dL, we plotted a receiver operating characteristic (ROC) curve. The area under the ROC curve was 0.78, and the maximal sum of sensitivity and specificity (78% and 72%, respectively) was obtained at a 1,5-AG cutoff level of <14.2 μg/mL. We conclude that 1,5-AG values may provide an ancillary predictor of 2h-PG of 75 g OGTTs in routine medical checkups.

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Section: Discussionmentioning

confidence: 99%

Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests

et al. 2011

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“…It is known that the MIN6 cell line, which is more sensitive to AG-stimulated insulin secretion, closely resembles normal pancreatic β-cells in glucose metabolism and glucose-dependent insulin secretion [36]. Studies have shown that pancreatic β-cells possess a unique AG transport system [37], which may be involved in the effects of AG. Additional studies are needed to have a better understanding on the molecular basis of AG in insulin secretion in insulinoma cell lines, isolated islets and rodent models.…”

Section: The Roles Of Af and Its Derivative Ag In Stimulation Of Insumentioning

confidence: 99%

1,5-Anhydro-D-Fructose and its Derivatives: Biosynthesis, Preparation and Potential Medical Applications

Fiskesund

Abeyama²,

Yoshinaga³

et al. 2010

Planta Med

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“…42 It is actively absorbed or reabsorbed in the intestine and renal tubules. 43 So when the concentration of blood glucose decreases, the competitive inhibition to the reabsorption of the 1,5-AG is alleviated followed by the decrease of the content of 1,5-AG in the urine, and the levels in serum become normal. So, the effective regulation of blood sugar by repaglinide was further veried by monitoring the decrease of 1,5-AG in the urine of the mice.…”

Section: Second Data Setmentioning

confidence: 99%

Interpretation of type 2 diabetes mellitus relevant GC-MS metabolomics fingerprints by using random forests

et al. 2013

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Transport of 1,5-anhydro-D-glucitol into insulinoma cells by a glucose-sensitive transport system

Cited by 9 publications

References 44 publications

Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests

Correlation between baseline serum 1,5-anhydroglucitol levels and 2-hour post-challenge glucose levels during oral glucose tolerance tests

1,5-Anhydro-D-Fructose and its Derivatives: Biosynthesis, Preparation and Potential Medical Applications

Interpretation of type 2 diabetes mellitus relevant GC-MS metabolomics fingerprints by using random forests

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