Transport of lipid vesicles via the cilia logistic network in the brain of mice

Abstract

v Moreover, liposome attachment was shown to depend on the lipid composition used for liposome preparation. These results indicate, that cargo and target site specific interaction is needed in addition to site specific delivery of the cargo by the CLN.Following these results, exosomes secreted from Z310 rat choroid plexus cells were isolated from cell culture supernatant, characterized, fluorescently-labelled and applied to the cilia-generated near wall flow of v3V. The results suggest, that exosomes are transported along the CLN similarly to liposomes. Further experiments are needed to clarify the transport and interaction of exosomes within the CLN in detail. vi Contents List of Figures xi Symbols and Abbreviations xiii 4 Discussion 894.1 Transport of extracellular vesicle like cargo in cilia-generated flow of the v3V .