2005
DOI: 10.1016/j.jconrel.2005.03.005
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Transport of nerve growth factor encapsulated into liposomes across the blood–brain barrier: In vitro and in vivo studies

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Cited by 156 publications
(106 citation statements)
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“…The liposomes in this study have a mean size of 104 nm. This size is optimal for nanoparticles to cross the bloodbrain barrier (42,43); moreover, smaller liposomes have a relatively extended half-life (44). In addition, the antitumor The results show highest affinities of the liposomes from GBM and relatively less, but still detectable, affinities from pilocytic astrocytoma.…”
Section: Discussionmentioning
confidence: 96%
“…The liposomes in this study have a mean size of 104 nm. This size is optimal for nanoparticles to cross the bloodbrain barrier (42,43); moreover, smaller liposomes have a relatively extended half-life (44). In addition, the antitumor The results show highest affinities of the liposomes from GBM and relatively less, but still detectable, affinities from pilocytic astrocytoma.…”
Section: Discussionmentioning
confidence: 96%
“…Isolation and Characterization of Rat Astrocytes (As) 14,15) The isolation procedure of astrocytes from rat brain was as follows: the cortex of brain of SD rat 12 h after birth was dissected free of meanings, cut away and minced into 1-2 mm cube, then centrifuged at a speed of 1000 rpm/min for 10 min. The sediments were digested in 0.25% trypsin at 37°C for 20 min.…”
Section: Methodsmentioning
confidence: 99%
“…Permeability of the BBB Model 14) ADM was selected as an indicator to evaluate the permeability of the BBB model. Confluent ECV304/As was selected as the BBB model, which was judged by TEER primarily.…”
Section: Methodsmentioning
confidence: 99%
“…112 In cerebrovascular system disorders, several substances prepared in liposomal form have been shown to be more beneficial compared to their "naked" forms. Nerve growth factor (NGF) is a peptide that was evaluated for its beneficial 113 Sterically-stabilized liposomes (SSLs) loaded with NGF (NGF-SSL) were tested in an in vitro model of the BBB using brain microvascular ECs (BMVECs). Compared to naked NGF, NGF-SSL achieved better penetration through the BMVEC and NGF loaded into conventional liposomes.…”
Section: Liposomesmentioning
confidence: 99%