2016
DOI: 10.1016/j.colsurfb.2015.12.029
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Transport of stearic acid-based solid lipid nanoparticles (SLNs) into human epithelial cells

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Cited by 53 publications
(22 citation statements)
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“…However, previous research of uptake of microwave-produced solid lipid nanoparticles (SLNs) indicated that clathrin-mediated route was the most preferred pathway [ 29 , 39 ]. The difference between our results may be attributed to the differences in surface properties, droplet size, and lipid condition.…”
Section: Resultsmentioning
confidence: 99%
“…However, previous research of uptake of microwave-produced solid lipid nanoparticles (SLNs) indicated that clathrin-mediated route was the most preferred pathway [ 29 , 39 ]. The difference between our results may be attributed to the differences in surface properties, droplet size, and lipid condition.…”
Section: Resultsmentioning
confidence: 99%
“…PLA-NP endocytosis mediated by clathrin-coated pits occurred within 60 min, where the major levels of internalization may be attributed to a quick mechanism ranging from ~45 to ~80 s. This involves different stages such as initiation, growth, stabilization and pit commitment cargo capture, budding and scission, and finally uncoating [ 33 ]. Previously, it was suggested that poly(lactic-co-glycolic acid) NP (PLGA-NP) and solid lipid NP uptake occurred mainly through a clathrin-dependent manner in lung epithelial A549 cells, using hypertonic sucrose medium [ 61 , 67 , 68 ]. However, it is well known that hypertonic sucrose medium also inhibits the uptake of cholera toxin, a lipid raft ligand [ 12 ].…”
Section: Discussionmentioning
confidence: 99%
“…Previously, microwave heating has been utilized to prepare lipid-based nanoparticles with diameters between 100 nm to 300 nm in 10 minutes [21, 22, 38]. Furthermore, the phase inversion temperature (PIT) method has been reported [31–34] to show nanoparticle sizes below 100 nm [39–42].…”
Section: Discussionmentioning
confidence: 99%