Transport Properties of Carbohydrates: Towards the Minimization Toxicological Risks of Cobalt and Chromium Ions

Abstract

The influence of oligosaccharides (α-cyclodextrin, β-cyclodextrin and γ-cyclodextrin), and a polysaccharide, sodium hyaluronate (NaHy), on the diffusion of aqueous solutions of cobalt and chromium chlorides has been investigated. Cobalt and chromium are constituents of metal alloys for biomedical use, including dental prostheses. Thus, the release of these ions in the human body can lead to harmful biological effects. The interaction of metal ions with saccharides might have information on the role of mouthwashes in preventing these effects. This interaction has been assessed by measuring multicomponent intermolecular diffusion coefficients at 298.15 K. It has been found that β-cyclodextrin has the highest interaction towards cobalt and chromium ions. This work will contribute to unveiling the mechanisms responsible for transport by diffusion in aqueous solutions, and, therefore, mitigating the potential toxicity inherent to those metal ions.

Transport Properties in Multicomponent Systems Containing Cyclodextrins and Nickel Ions

“…Their wide use in the pharmaceutical field is due to factors, such as low toxicity and safety for human use, low immunogenicity, good cost-effectiveness, and availability. In addition, they are not subject to microbial resistance, increase the stability and solubility of drugs while improving their absorption, mask unpleasant tastes or unwanted odors of certain compounds, regulate the controlled release of drugs, mitigate local and systemic toxicity, improve permeability across biological barriers [3,[25][26][27][28][29], and mitigate local and systemic toxicity [22,30].…”