Transport proteins of the ABC family and multidrug resistance of tumor cells

Abstract

Some new data concerning the role of transport proteins of the ABC family in multidrug resistance (MDR) of human tumor cells, and problems connected with regulation of these proteins are considered. MDR is a complex phenomenon that may be caused simultaneously by several mechanisms functioning in one and the same cell. Among them there may be the alterations of activity of several transport proteins. Activation of these proteins may be associated with alterations of activities of different cell protective systems and of the signal transduction pathways involved in regulation of proliferation, differentiation, and apoptosis. Clinical significance of multifactor MDR is discussed.

Down-regulating HIF-1α by lentivirus-mediated shRNA for therapy of triple negative breast cancer

“…41 Hypoxia induces cellular adaptations which contribute to cancer progression and chemoresistance, with one of these adaptations being the expression of multidrug resistance proteins such as ABC transporters. 42 Evidence of MDR-1 or MRP1 upregulation through HIF-1 under hypoxia has recently been highlighted. 43,44 In the present study, we observed increased chemosensitivity to THP in HIF-1a shRNA-treated cells, compared with NC shRNA treated or untreated cells, supporting the notion that the combination of gene therapy and chemotherapy may be a new hope for TNBC treatment.…”

Molecular signature of cancer stem cells isolated from prostate carcinoma and expression of stem markers in different Gleason grades and metastasis

“…The presence of a side population has been also reported in PCa cells (Pascal et al 2007). Interestingly, ABC transporters are thought to be responsible for drug resistance in most cancers (Sharom 2008;Stavrovskaya andStromskaya 2008), including PCa (Sánchez et al 2009;Sánchez et al 2011).…”

Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line

“…It has been observed that one of the most common mechanisms of cancer MDR is the over-expression of the efflux pumps 29 , which are membrane proteins that can recognise and extrude out of the cells toxic agents such as the anticancer drugs 29,30 . In this context, different studies 6,7,[14][15][16][31][32][33] pointed out that selenocompounds can enhance the activity of the drugs used in cancer chemotherapy in a synergic way if they are applied together.…”