Transporters in the Lactating Mammary Epithelium

Neville, Margaret C.; Kamikawa, Akihiro; Webb, Patricia G.; Ramanathan, Palaniappan

doi:10.1007/978-3-030-55310-4_6

Cited by 4 publications

(1 citation statement)

References 220 publications

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“…Interestingly, the MFG often contains a fragment of cytoplasm that can be used to analyze the RNA composition of the milk secreting cell [ 30 , 31 ]. Pathway 3 ferries mono- and divalent ions as well as substrates like glucose and amino acids across both basal and apical membranes [ 32 ]. Pathway 4 is a direct vesicular pathway mainly involved in transferring IgA from the interstitial space where it is manufactured by resident B cells across the cytoplasm to be secreted as secretory IgA into the milk [ 33 ].…”

Section: Factors That Influence the Normal Secretion Of Milk: Anatomy...mentioning

confidence: 99%

Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 1

Neville¹,

Demerath

Hahn‐Holbrook

et al. 2023

The American Journal of Clinical Nutrition

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Section: Factors That Influence the Normal Secretion Of Milk: Anatomy...mentioning

confidence: 99%

Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 1

Neville¹,

Demerath

Hahn‐Holbrook

et al. 2023

The American Journal of Clinical Nutrition

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Milk Salts: Technological Significance

Lucey

Horne

2022

Advanced Dairy Chemistry

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Method for evaluating milk production in mouse mammary gland

Sakai,

Kamikawa

2024

Animal Science Journal

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Lactation is a characteristic physiological function of mammals and is important for nourishing infants and the dairy industry; however, the molecular mechanisms underlying the function remain to be elucidated. A technique to directly evaluate the quantity and quality of milk in mice is necessary for the study of the lactation mechanism in vivo. By measuring the changes in milk amount after different durations of milk accumulation (0–24 h) using a ductal cannulation technique and oxytocin supplementation, we estimated the milk production rate at a single mammary gland level. In addition, collected milk was available to assess milk quality, including creamatocrit, osmolarity, and concentrations of ions, lactose, and total protein. Moreover, as a proof of principle, the effects of intraductal administration of a hypertonic solution to the abdominal mammary gland were examined. This stimulation increased milk amount, possibly by osmosis, compared with the contralateral control gland. These results demonstrated that this method is useful for examining the lactation ability and mechanisms in vivo. Studies using this method will contribute to the further understanding of lactation mechanisms in mammals.

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Transporters in the Lactating Mammary Epithelium

Cited by 4 publications

References 220 publications

Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 1

Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition—a report from “Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)” Working Group 1

Milk Salts: Technological Significance

Method for evaluating milk production in mouse mammary gland

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