Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein

Pörschke, Marius; Rodríguez-González, Inés; Parfentev, Iwan; Urlaub, Henning; Kehlenbach, Ralph H.

doi:10.1016/j.jbc.2023.102932

Journal of Biological Chemistry

2023

DOI: 10.1016/j.jbc.2023.102932

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Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein

Marius Pörschke¹,

Inés Rodríguez-González²,

Iwan Parfentev³

et al.

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2024

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Cited by 3 publications

References 66 publications

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Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2

Wang,

Peng,

Yang

et al. 2024

iScience

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Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2

Wang,

Peng,

Yang

et al. 2024

iScience

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Androgens and erectile dysfunction: from androgen deficiency to treatment

Wang,

Jiang

2024

Sexual Medicine Reviews

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Introduction Androgens play important roles in regulating the growth and development of the male reproductive system and maintaining libido and erectile function. The specific mechanisms by which androgen deficiency leads to erectile dysfunction (ED) are not yet fully understood. Objectives To understand the mechanisms and treatment of androgen deficiency–related ED. Methods A literature search in the past 10 years was conducted in PubMed and Google Scholar to determine the effects of androgen deficiency on erectile function and the treatment of androgen deficiency. Results Androgen deficiency can be caused by hypothalamic-pituitary lesions and injuries, testicular-related diseases and injuries, endocrine and metabolic disorders, the side effects of medication, and age. Androgen deficiency can lead to ED by inhibiting the NOS/NO/cGMP pathway (nitric oxide synthase/nitric oxide/cyclic guanosine monophosphate) and altering the expression of ion channel proteins, as well as by inducing oxidative stress, death, and fibrosis in penile corpus cavernosum cells. Testosterone replacement therapy is effective at improving the serum testosterone levels and erectile function in patients with androgen deficiency. For patients who need to maintain a low androgenic state, erectile function can be improved by lifestyle changes, treatment with phosphodiesterase type 5 inhibitors, low-intensity extracorporeal shock wave therapy, and stem cell therapy. Conclusions Androgen deficiency can affect the structure and function of the penile corpus cavernosum, leading to ED. Areas of further study include how androgen replacement therapy can improve erectile function and how to improve the maintenance of erectile function in patients with hypoandrogenic status.

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Subcellular Localization Guides eNOS Function

Villadangos,

Serrador

2024

IJMS

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Nitric oxide synthases (NOS) are enzymes responsible for the cellular production of nitric oxide (NO), a highly reactive signaling molecule involved in important physiological and pathological processes. Given its remarkable capacity to diffuse across membranes, NO cannot be stored inside cells and thus requires multiple controlling mechanisms to regulate its biological functions. In particular, the regulation of endothelial nitric oxide synthase (eNOS) activity has been shown to be crucial in vascular homeostasis, primarily affecting cardiovascular disease and other pathophysiological processes of importance for human health. Among other factors, the subcellular localization of eNOS plays an important role in regulating its enzymatic activity and the bioavailability of NO. The aim of this review is to summarize pioneering studies and more recent publications, unveiling some of the factors that influence the subcellular compartmentalization of eNOS and discussing their functional implications in health and disease.

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Transportin 1 is a major nuclear import receptor of the nitric oxide synthase interacting protein

Cited by 3 publications

References 66 publications

Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2

Proteome and ubiquitinome analyses of the brain cortex in K18-hACE2 mice infected with SARS-CoV-2

Androgens and erectile dysfunction: from androgen deficiency to treatment

Subcellular Localization Guides eNOS Function

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