Transposition of the Great Arteries

Mavroudis, Constantine; Backer, Carl L.; Herrmann, Jeremy L.

doi:10.1002/9781119282327.ch25

Cited by 2 publications

(6 citation statements)

References 269 publications

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Section: Discussionmentioning

confidence: 99%

“…TGA is a congenital cardiac defect resulting from abnormal development of the aorta and pulmonary trunk during embryogenesis [18]. This condition is characterized by the aorta arising from the right ventricle and the pulmonary trunk arising from the left ventricle in a discordant manner [18]. Consequently, this abnormality creates two parallel circulation circuits, leading to the delivery of deoxygenated blood to the systemic circulation, rendering it incompatible with life [19].…”

Section: Discussionmentioning

confidence: 99%

“…Consequently, this abnormality creates two parallel circulation circuits, leading to the delivery of deoxygenated blood to the systemic circulation, rendering it incompatible with life [19]. However, patients with concomitant patent ductus arteriosus or ventricular septal defects can survive, as they allow the mixing of oxygen-rich blood from the opposing circulation circuit [18]. Typically, survival rates are low in patients with uncorrected TGA, with mortality rates reaching approximately 30% in the first week of life and as high as 90% by the end of the first year [18].…”

Section: Discussionmentioning

confidence: 99%

“…However, patients with concomitant patent ductus arteriosus or ventricular septal defects can survive, as they allow the mixing of oxygen-rich blood from the opposing circulation circuit [18]. Typically, survival rates are low in patients with uncorrected TGA, with mortality rates reaching approximately 30% in the first week of life and as high as 90% by the end of the first year [18]. Although survival facilitated by a communication defect is not without complications, such as the development of polycythemia, hyperviscosity syndrome, congestive heart failure, ventricular arrhythmias, and delayed developmental milestones [18].…”

Section: Discussionmentioning

confidence: 99%

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Bacterial Brain Abscesses in a Patient With Transposition of the Great Arteries and Interventricular Communication

Gómez-Gutiérrez,

Morelos-Ulibarri,

Trejo-Ponce de Leon

et al. 2023

Cureus

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Brain abscesses are localized infections in the brain's parenchyma, characterized by inflammation, pus formation, and the development of a surrounding capsule. These lesions typically occur due to underlying factors such as immunosuppression, ear and sinus infections, and contamination during neurosurgery. While brain abscesses are a life-threatening complication of cyanotic heart defects, they are rarely reported, with only sporadic cases previously documented. This article presents the case of an eight-year-old male patient with an uncorrected transposition of the great arteries, who was evaluated for symptoms including headache, fever, and neurological focalization. Diagnostic imaging revealed three lesions consistent with brain abscesses. Furthermore, the causal agents were identified as Streptococcus intermedius and Fusobacterium spp., representing oral microorganisms. Additionally, the patient exhibited poor oral hygiene and dental caries in multiple teeth. This article discusses and integrates the possible pathophysiological mechanisms that allowed a localized dental infection to spread hematogenously and cause brain abscesses in this patient. Prompt management of the infectious source is crucial to prevent a poor prognosis associated with brain abscesses. Therefore, this case emphasizes the importance of regular dental assessments and thromboprophylaxis for patients with underlying cardiomyopathies that cause right-to-left shunting to prevent potential complications.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Bacterial Brain Abscesses in a Patient With Transposition of the Great Arteries and Interventricular Communication

Gómez-Gutiérrez,

Morelos-Ulibarri,

Trejo-Ponce de Leon

et al. 2023

Cureus

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“…Balloon atrial septostomy (BAS) is an emergent and essential cardiac interventional procedure to stabilize neonates with congenital heart diseases (CHD) with physiology of restrictive atrial communication, such as patients with transposition of the great arteries (TGA). [1][2][3] The enlargement of interatrial communication by BAS enhances atrial level mixing of oxygenated and deoxygenated blood from parallel pulmonary and systemic circulation and improves systemic hypoxia and acidosis. 2 BAS was first performed by Rashkind and Miller in 1966 and is currently still a lifesaving procedure for TGA neonates with severe oxygen desaturation after birth.…”

Section: Introductionmentioning

confidence: 99%

Balloon atrial septostomy for transposition of the great arteries: Safety and experience with the Z‐5 balloon catheter

Weeda,

Bokenkamp‐Gramann,

Straver

et al. 2023

Cathet Cardio Intervent

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BackgroundBalloon atrial septostomy (BAS) is an emergent and essential cardiac intervention to enhance intercirculatory mixing at atrial level in deoxygenated patients diagnosed with transposition of the great arteries (TGA) and restrictive foramen ovale. The recent recall of several BAS catheters and the changes in the European legal framework for medical devices (MDR 2017/745), has led to an overall scarcity of BAS catheters and raised questions about the use, safety, and experience of the remaining NuMED Z‐5 BAS catheter.AimsTo evaluate and describe the practice and safety of the Z‐5 BAS catheter, and to compare it to the performance of other BAS catheters.MethodsA retrospective single‐center cohort encompassing all BAS procedures performed with the Z‐5 BAS catheter in TGA patients between 1999 and 2022.ResultsA total of 182 BAS procedures were performed in 179 TGA‐newborns at Day 1 (IQR 0–5) days after birth, with median weight of 3.4 (IQR 1.2–5.7) kg. The need for BAS was urgent in 90% of patients. The percentage of BAS procedures performed at bedside increased over time from 9.8% (before 2010) to 67% (2017–2022). Major complication rate was 2.2%, consisting of cerebral infarction (1.6%) and hypovolemic shock (0.5%). The rate of minor complications was 9.3%, including temporary periprocedural AV‐block (3.8%), femoral vein thrombosis (2.7%), transient intracardiac thrombus (0.5%), and atrial flutter (2.2%). BAS procedures performed at bedside and in the cardiac catheterization laboratory had similar complication rates.ConclusionsBAS using the Z‐5 BAS catheter is both feasible and safe at bedside and at the cardiac catheterization laboratory with minimal major complications.

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Transposition of the Great Arteries

Cited by 2 publications

References 269 publications

Bacterial Brain Abscesses in a Patient With Transposition of the Great Arteries and Interventricular Communication

Bacterial Brain Abscesses in a Patient With Transposition of the Great Arteries and Interventricular Communication

Balloon atrial septostomy for transposition of the great arteries: Safety and experience with the Z‐5 balloon catheter

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