Transpupillary Thermotherapy for Circumscribed Choroidal Hemangioma: Clinical Profile and Treatment Outcome

Sharma, Tarun; Krishnan, Tandava; Gopal, Lingam; Nagpal, Amit; Khetan, Vikas; Rishi, Pukhraj

doi:10.3928/15428877-20110707-01

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…The proposed mechanism includes vascular thrombosis, thermal inhibition of angiogenesis and induction of fibrosis. TTT has been established as an optional treatment for choroidal melanomas[ 16 ] and hemangiomas[ 17 ] and was effective in causing the regression of tumors. TTT has also been reported as an effective treatment method for small solitary choroidal metastases with minimal subretinal fluid located in the posterior pole.…”

Section: Discussionmentioning

confidence: 99%

The effect of intravitreal bevacizumab and transpupillary thermotherapy on choroidal metastases and literature review

Lin

Tsai

2015

Indian J Ophthalmol

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Aims:To represent the effects of transpupillary thermotherapy (TTT) and intravitreal bevacizumab on choroidal metastases and review the literature.Settings and Design:A retrospective, interventional, noncomparative case series.Materials and Methods:A retrospective, interventional, noncomparative case series of five eyes in three patients with choroidal metastases was conducted. Fundus findings of choroidal metastases were divided into two types: Solitary or diffuse type. The size of the tumor was termed small (<10 mm diameter), medium (10–15 mm diameter) or large (>15 mm diameter). All eyes received one session of TTT followed by 3 weekly intravitreal bevacizumab injections as an adjuvant therapy. The parameters of treatment for TTT were 1.2–3 mm spot size, 150–300 mW, 60 s with the whole lesion covered confluently. The changes in preoperative and postoperative best-corrected visual acuity (BCVA) were recorded. Serial color fundus photography and optical coherent tomography were performed to measure the treatment efficacy.Results:All eight choroidal metastases were solitary type. The size of six tumors was small, the size of one tumor was medium, and the size of one tumor was large. All five eyes of the three patients had improvement of BCVA after treatment. Fundus photos revealed tumor shrinkage and the mean shrinkage percentage was 61.27 ± 21.71%. Optical coherence tomography revealed complete resolution of serous retinal detachment. There was no recurrence after 6 months follow-up.Conclusions:TTT combined with intravitreal bevacizumab injections brought about beneficial effects in reducing tumor size and improving vision in all five eyes of the three patients. Despite the retrospective nature of our study, the absence of control group and the size limitation that, of course, limit the statistical power, TTT combined with intravitreal bevacizumab seems to be efficient in providing another cost-reducing and time-saving treatment option for patients with choroidal metastases. The antineoplastic properties of bevacizumab make it a viable adjunctive therapy. Studies with more cases and a longer follow-up period are warranted.

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Section: Discussionmentioning

confidence: 99%

The effect of intravitreal bevacizumab and transpupillary thermotherapy on choroidal metastases and literature review

Lin

Tsai

2015

Indian J Ophthalmol

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“…It is helpful in total reabsorption of serous retinal detachment thereby re-attaching the retina and improving the visual acuity. The disadvantages of TTT are CME, choroidal atrophy, RPE hypertrophy, pre-retinal fibrosis, focal iris atrophy and retinal vascular occlusions [8,9,33].…”

Section: Laser Therapiesmentioning

confidence: 99%

Role of Radiation Therapy for Choroidal Hemangioma: A Brief Review

Turaka¹

2016

J Clin Res Ophthalmol

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“…Оценивая ОКТ-симптоматику ГХ, можно сказать, что нарушение архитектоники сетчатки, в том числе ее кистозная дистрофия, возникают при проминенции опухоли более 1,8 мм, а отек сетчаткичаще при ее большей толщине [15]. В то же время имеются сведения, что куполообразная элевация хориоидеи с фокальной гиперплазией надлежащего РПЭ может сочетаться с серозной отслойкой сетчатки над опухолью и сохранной архитектоникой сетчатки, нормальным слоем фоторецепторов и отсутствием интраретинального отека [9,16], что расценивают как отражение остроты процесса [6].…”

Section: рис 4 окт-горизонтальный срезunclassified

Precise diagnosis of choroidal hemangioma

et al. 2016

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Transpupillary Thermotherapy for Circumscribed Choroidal Hemangioma: Clinical Profile and Treatment Outcome

Abstract: Macula-sparing TTT was effective in causing regression of CCH and resorption of associated exudative retinal detachment, and helped in preserving or improving vision in 81% of treated eyes.

Cited by 9 publications

References 16 publications

The effect of intravitreal bevacizumab and transpupillary thermotherapy on choroidal metastases and literature review

The effect of intravitreal bevacizumab and transpupillary thermotherapy on choroidal metastases and literature review

Role of Radiation Therapy for Choroidal Hemangioma: A Brief Review

Precise diagnosis of choroidal hemangioma

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